약학회지 (YAKHAK HOEJI)
- 제44권6호
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- Pages.572-577
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- 2000
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
이부프로펜이 씨프로플록사신의 생체이용률에 미치는 영향
Effects of Ibuprofen on Bioavailability of Ciprofloxacin
- Park, In-Sook (Korea Food and Drug Administration, National Institute of Toxicological Research) ;
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Choi, Ki-Hwan
(Korea Food and Drug Administration, National Institute of Toxicological Research) ;
- Na, Han-Kwang (Korea Food and Drug Administration, National Institute of Toxicological Research) ;
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Chung, Hye-Joo
(Korea Food and Drug Administration, National Institute of Toxicological Research)
- 발행 : 2000.12.30
초록
The effects of ibuprofen on bioavailability of ciprofloxacin were studied in rabbits. Animals were divided into three groups ; group A received 60 mg/kg of ciprofloxacin; group B and C received 60 mg/kg of ciprofloxacin with 60 and 240 mg/kg of ibuprofen, respectively. Ciprofloxacin and ibuprofen were given by single oral administration. Serum concentrations of ciprofloxacin were measured by high performance liquid chromatography with UV detector and pharmacokinetic parameters were calculated. Area under the serum concentrations versus time curve (