YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Ibuprofen on Bioavailability of Ciprofloxacin

이부프로펜이 씨프로플록사신의 생체이용률에 미치는 영향

  • Park, In-Sook (Korea Food and Drug Administration, National Institute of Toxicological Research) ;
  • Choi, Ki-Hwan (Korea Food and Drug Administration, National Institute of Toxicological Research) ;
  • Na, Han-Kwang (Korea Food and Drug Administration, National Institute of Toxicological Research) ;
  • Chung, Hye-Joo (Korea Food and Drug Administration, National Institute of Toxicological Research)
  • 박인숙 (식품의약품안전청 국립독성연구소) ;
  • 최기환 (식품의약품안전청 국립독성연구소) ;
  • 나한광 (식품의약품안전청 국립독성연구소) ;
  • 정혜주 (식품의약품안전청 국립독성연구소)
  • Published : 2000.12.30
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Abstract

The effects of ibuprofen on bioavailability of ciprofloxacin were studied in rabbits. Animals were divided into three groups ; group A received 60 mg/kg of ciprofloxacin; group B and C received 60 mg/kg of ciprofloxacin with 60 and 240 mg/kg of ibuprofen, respectively. Ciprofloxacin and ibuprofen were given by single oral administration. Serum concentrations of ciprofloxacin were measured by high performance liquid chromatography with UV detector and pharmacokinetic parameters were calculated. Area under the serum concentrations versus time curve (${\pm}\;S.E.$) of ciprofloxacin were decreased in group B and C compared with group A ($12.26\;{\pm}\;0.94$ and $12.57\;{\pm}\;0.94$ vs. $15.71\;{\pm}\;1.06\;{\mu}g{\cdot}hr/ml$, p<0.05), whereas total clearances were increased ($1.81\;{\pm}\;0.13$ and $1.76\;{\pm}\;0.12$ vs. $1.40\;{\pm}\;0.09\;l/hr/kg$, p<0.05). No significant differances in these parameters were observed between group B and C. Relative bio-availability of group B and C to group A were 78 and 80%, respectively. These results suggest that the coadministration of ibuprofen with ciprofloxacin may reduce the bioavailability of ciprofloxacin.

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