Synthes is of 9,10-difluoro-5,6,6a,7,11b-pentahydroindano [2,1-c]isoquinoline

9,10- 디플루오르 -5,6,6a,7,11b- 펜타하이드로인다노[2,1-c] 이소퀴놀린의 합성

The synthesis of pentahydroindanoisoquinoline (4) compound has been achieved via the cyclization of 2-(N-benzylamino)-5,6-difluoro-1-indanol (10a, 10b), which was prepared by condensation and reduction of 2-amino-1-indanol and benzaldehyde in ethanol. The stereochemistry of $H_{6a}$ and $H_{11b}$ of 9,10-difluoro-5,6,6a,7,11b-pentahydroindano[2,1-c]isoquinoline (4) was the trans B/C ring fusion.