BMB Reports
- Volume 32 Issue 3
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- Pages.232-238
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- 1999
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- 1976-670X(eISSN)
Gender Differences in Activity and Induction of Hepatic Microsomal Cytochrome P-450 by 1-Bromopropane in Sprague-Dawley Rats
- Kim, Ki-Woong (Industrial Health Research Institute, KISCO) ;
- Kim, Hyeon-Yong (Industrial Health Research Institute, KISCO) ;
- Park, Sang-Shin (Industrial Health Research Institute, KISCO) ;
- Jeong, Hyo-Seok (Industrial Health Research Institute, KISCO) ;
- Park, Sang-Hoi (Public Health Faculty of Medicine, University of Tokyo) ;
- Lee, Jun-Yeon (Industrial Health Research Institute, KISCO) ;
- Jeong, Jae-Hwang (Industrial Health Research Institute, KISCO) ;
- Moon, Young-Hahn (Industrial Health Research Institute, KISCO)
- Received : 1998.11.09
- Accepted : 1998.12.16
- Published : 1999.05.31
Abstract
Sex differences in the induction of microsomal cytochrome P-450 (CYP) and the activities of several related enzymes of Sprague-Dawley rats treated with 1-bromopropane (1-BrP) were investigated. Male and female rats were exposed to 50, 300, and 1800 ppm of 1-BrP per kg body weight (6 h a day,S days a week, 8 weeks) by inhalation. The mean body weight of 1-BrP treated groups increased according to the day elapsed, but four and five weeks respectively after the start of the exposure, the mean body weight of male and female rats had significantly reduced in the group treated with 1800 ppm 1-BrP compared with the control group (p<0.01). While the relative weights of liver increased in both sexes, statistical significance in both sexes was found only in the group receiving 1800 ppm/kg of 1-BrP (p<0.01). The total contents of CYP,
Keywords
- 1-Bromopropan;
- Cytochrome;
- P-4502E1;
- Cytochrome P-450 dependent monooxygenase;
- Glutathione S-transferase