Tuberculosis and Respiratory Diseases
- 제47권5호
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- Pages.691-696
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- 1999
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
폐의 유상피성 혈관내피종 1예
A Case of Pulmonary Epithelioid Hemangioendothelioma
- 김관영 (경북대학교 의과대학 내과학교실) ;
- 김창호 (경북대학교 의과대학 내과학교실) ;
- 손지웅 (경북대학교 의과대학 내과학교실) ;
- 차승익 (경북대학교 의과대학 내과학교실) ;
- 채상철 (경북대학교 의과대학 내과학교실) ;
- 박재용 (경북대학교 의과대학 내과학교실) ;
- 정태훈 (경북대학교 의과대학 내과학교실) ;
- 박태인 (경북대학교 의과대학 병리학교실) ;
- 권건영 (경북대학교병원 호흡기센타)
- Kim,, Kwan-Young (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Kim, Chang-Ho (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Sohn, Ji-Wung (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Cha, Seung-Ick (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Chae, Sang-Chul (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Park, Jae-Yong (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Jung, Tae-Hoon (Department of Internal Medicine, College of Medicine, Kyungpook National University) ;
- Park, Tae-In (Department of Pathology, College of Medicine, Kyungpook National University) ;
- Kwon, Keun-Yeung (Department of Pathology, College of Medicine, Kyemyung University)
- 발행 : 1999.11.30
초록
건강검진시 촬영한 단순흉부사진에서 우연히 발견된 다발성 결절로 내원한 34세 여자 환자에서 개흉술을 통한 조직검사상 미분화 혈관분화를 보이고 면역조직 화학염색상 제 VIII 인자-관련인자, CD34 와 vimentin에 양성반응을 보여 EH로 확진 되었던 1예를 경험하였기에 보고하는 바이다.
Epithelioid hemangioendothelioma(EH) is a rare pulmonary vascular malignancy. Clinically, EH has been considered as an indolent, generally non-aggressive tumor. We report a case of EH which was confirmed by open lung biopsy. A 34-year-old woman was admitted for further evaluation of multiple small(less than 2cm in size) nodules, incidentally detected on screening chest radiograph. The chest CT showed multiple, relatively well-marginated, variable sized nodules at both whole lung. Transbronchial lung biopsy and transthoracic needle aspiration were nondiagnostic and open lung biopsy was performed from right middle lobe of lung. On light-microscopic examination, the nodules were composed of a poorly cellular hyaline core and a more cellular peripheral zone which extended into air space in a micropolypoid fashion and obliterated blood vessels. The tumor cells at the peripheral zone had intracytoplasmic vacuoles which suggested primitive, vascular differentiation. Immuno-histochemical study revealed the cellular area which gave positive reaction to factor VIII-related antigen. She received no specific therapy after open lung biopsy and chest X-ray films had showed no change for about two years.