Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Urinary 5-hydroxyindoleacetic Acid(5-HIAA) Excretion Before and During Cisplatin Chemotherapy in Patients with Intrathoracic Malignancy

흉곽내 악성종양환자에서 Cisplatin 투여시 5-hydroxyindoleacetic Acid (5-HIAA)의 변화

  • Yang, Dong-Gyoo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Yoon-Soo (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Young-Sam (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Jun-Gu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ahn, Kang-Hyun (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Jae-Min (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Se-Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chung, Hyun-Cheol (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Joon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Ahn, Chul-Min (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Sung-Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Lee, Won-Young (Department of Internal Medicine, Yonsei University College of Medicine)
  • 양동규 (연세대학교 의과대학 내과학교실) ;
  • 장윤수 (연세대학교 의과대학 내과학교실) ;
  • 김영삼 (연세대학교 의과대학 내과학교실) ;
  • 이준구 (연세대학교 의과대학 내과학교실) ;
  • 박재민 (연세대학교 의과대학 내과학교실) ;
  • 안강현 (연세대학교 의과대학 내과학교실) ;
  • 김세규 (연세대학교 의과대학 내과학교실) ;
  • 정현철 (연세대학교 의과대학 내과학교실) ;
  • 장준 (연세대학교 의과대학 내과학교실) ;
  • 안철민 (연세대학교 의과대학 내과학교실) ;
  • 김성규 (연세대학교 의과대학 내과학교실) ;
  • 이원영 (연세대학교 의과대학 내과학교실)
  • Published : 1999.06.30
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Abstract

Background : Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of $5-HT_3$ receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin. Methods : Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleaoetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis. Results : Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002). Conclusion : Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding may provide evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.

Keywords

Acknowledgement

Supported by : 연세대학교