Journal of Ginseng Research
- 제23권1호
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- Pages.38-43
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- 1999
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Effect of Spinally Administered Ginseng Total Saponin on Capsaicin-Induced Pain and Excitatory Amino Acids-Induced Nociceptive Responses
- Nah Jin-Ju (Department of Physiology, College of Veterinary Medicine) ;
- Choi Seok (Department of Physiology, College of Veterinary Medicine) ;
- Kim Yoon-Hee (Department of Physiology, College of Veterinary Medicine) ;
- Kim Seok-Chang (Korea Ginseng and Tobacco Research Institute) ;
- Nam Ki-Yeul (Korea Ginseng and Tobacco Research Institute) ;
- Kim Jong-Keun (Department of Pharmacology College of Medicine, Chonnam National University) ;
- Nah Seung-Yeol (Department of Physiology, College of Veterinary Medicine)
- 발행 : 1999.03.01
초록
진세노사이드(ginseng total saponin)는 인삼의 주요 약리학적 성분이다. 본 연구는 척수강내로 투여된 진세노사이드가 캡사이신에 의하여 유도된 통증을 억제하는가를 연구하였다. 진세노사이드의 척수강내 전투여는 캡사이신에 의하여 유도되는 통증을 투여 용량에 의존적으로 억제하였다. 통증 억제 효과를 나타내는
Ginseng total saponins (ginsenosides) are biologically active main ingredients of Panax ginseng. In present study, we have investigated whether pretreatment of ginsenosides inhibited capsaicin-induced pain at the spinal level, in the view that capsaicin causes substance P (SP) release from primary afferents. Ginsenosides relieved capsaicin-induced pain in a dose-dependent manner. The