Korean Journal of Head & Neck Oncology (대한두경부종양학회지)
- Volume 15 Issue 1
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- Pages.46-51
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- 1999
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- 1229-5183(pISSN)
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- 2586-2553(eISSN)
The Significance of Serum Thyroid Peroxidase as a New Tumor Marker in Papillary Thyroid Carcinoma after Thyroidectomy
유두상 갑상선암의 수술후 재발예측인자로서 혈청 Thyroid Peroxidase의 의의
- Chang Hang-Seok (Department of Surgery, Yonsei University College of Medicine) ;
- Na Jae-Wung (Department of Surgery, Yonsei University College of Medicine) ;
- Chung Woong-Youn (Department of Surgery, Yonsei University College of Medicine) ;
- Park Cheong-Soo (Department of Surgery, Yonsei University College of Medicine)
- Published : 1999.05.01
Abstract
Background: Total thyroidectomy and postoperative radiodiodine ablation therapy in differentiated thyroid carcinomas enhance the reliability of serum thyroglobulin(Tg) levels and radioiodine scan in detecting recurrence or distant metastasis. There have been, however, some limitations in using these methods under certain conditions. Recently, several reports have indicated that thyroid peroxidase(TPO) could be used as an alternative tumor marker. We aimed to estimate the significance of serum TPO levels in differentiated thyroid carcinoma. Materials and Methods: Forty-eight patients who had undergone total thyroidectomy due to papillary thyroid carcinomas and who had been followed-up for at least 3 years were classified into two groups: 27 patients without any evidence of recurrence in group 1; and 20 patients with recurrence or distant metastasis in group 2. All patients were examined by radioiodine scans. Serum Tg, TSH, antithyroglobulin antibody, and TPO were measured and the relationships were statistically analyzed. The sensitivity and specificity of