Korean Journal of Head & Neck Oncology (대한두경부종양학회지)
- Volume 15 Issue 1
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- Pages.3-8
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- 1999
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- 1229-5183(pISSN)
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- 2586-2553(eISSN)
Significance of Ki67 and p27 Reactivities in Various Thyroid Disorders
갑상선 결절의 Ki67과 p27 발현도에 대한 분석
- Park Cheong-Soo (Departments of Surgery, Yonsei University College of Medicine) ;
- Chung Woung-Youn (Departments of Surgery, Yonsei University College of Medicine) ;
- Chang Hang-Seok (Departments of Surgery, Yonsei University College of Medicine) ;
- Lee Mi-Kyung (Departments of Pathology, Yonsei University College of Medicine)
- Published : 1999.05.01
Abstract
Objective: The expression of Ki67, a proliferation marker, and p27, a cyclin dependent kinases(CDKs) inhibitor, has been studied in various human neoplasms. This study was carried out to determine whether these markers are useful in distinguishing benign from malignant lesions of the thyroid or predicting biologic behavior of malignant lesions. Material and Methods: Using immunohistochemical techniques with monoclonal antibodies to Ki67 and p27, we analyzed the expression of Ki67 and p27 in various thyroid disorders(25 follicular adenomas, 47 follicular carcinomas, 16 papillary carcinomas, 20 adenomatous goiters and 40 normal thyroid tissues). The labeling indices(LIs) were determined by counting cells expressing these markers in 1000 cells per immunostained slide. Results: Neoplastic thyroid diseases showed higher expression of Ki67 and lower expression of p27 than non-neoplastic diseases(p<0.05). The expression of p27 was significantly different between follicular adenomas(