Restorative Dentistry and Endodontics
- Volume 24 Issue 1
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- Pages.180-186
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- 1999
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- 2234-7658(pISSN)
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- 2234-7666(eISSN)
EFFECT OF EUGENOL ON REGULATION OF iCGRP RELEASE FROM THE BOVINE DENTAL PULP
치수에서 Eugenol이 iCGRP(immunoreactive calcitonin gene-related peptide)의 분비 조절에 미치는 영향
- Oh, Won-Mann (College of Dentistry, Institute of Dental Science Chonnam Nat. Uni.) ;
- Choi, Nam-Ki (College of Dentistry, Institute of Dental Science Chonnam Nat. Uni.) ;
- Kim, Sun-Hun (College of Dentistry, Institute of Dental Science Chonnam Nat. Uni.)
- Published : 1999.04.06
Abstract
Eugenol has been reported to reduce odontogenic pain and is known to have a structure similar to capsaicin, a potent stimulant of certain nociceptors. We have hypothesized that the analgesic effect of eugenol may be due, in part, to inhibition of capsaicin-sensitive nociceptors. To test this hypothesis, we evaluate whether eugenol inhibits capsaicin-sensitive release of immunoreactive calcitonin generated peptide(iCGRP) from bovine dental pulp. Freshly extracted bovine incisors were transported to the lab. on ice, Spilitted and pulp tissue was removed. The tissue was chopped into 200