Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Meta-analysis on the Blood Lipids as Risk Factors of Coronary Heart Diseases in Koreans

한국인 관상동맥성 심질환의 위험요인으로서 혈청지질에 관한 메타분석

  • Kim, Ki-Soon (Department of Preventive Medicine, College of Medicine, Chosun University) ;
  • Kim, Yang-Ok (Department of Preventive Medicine, College of Medicine, Chosun University) ;
  • Park, Jong (Department of Preventive Medicine, College of Medicine, Chosun University) ;
  • Park, Jong-Ku (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Chun-Bae (Department of Preventive Medicine, Yonsei University Wonju College of Medicine) ;
  • Jee, Sun-Ha (Graduate School of Health Science and Management, Yonsei University) ;
  • Ryu, So-Yeon (Department of Preventive Medicine, College of Medicine, Chosun University)
  • 김기순 (조선대학교 의과대학 예방의학교실) ;
  • 김양옥 (조선대학교 의과대학 예방의학교실) ;
  • 박종 (조선대학교 의과대학 예방의학교실) ;
  • 박종구 (연세대학교 원주의과대학 예방의학교실) ;
  • 김춘배 (연세대학교 원주의과대학 예방의학교실) ;
  • 지선하 (연세대학교 보건대학원) ;
  • 류소연 (조선대학교 의과대학 예방의학교실)
  • Published : 1999.12.01
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Abstract

Objectives : To determine the relations between seven blood lipids such as total cholesterol(TC), triglyceride(TG), HDL-cholesterol(HDL), LDL-cholesterol(LDL), apolipoprotein A-1(Apo A1), apolipoprotein B(Apo B) and lipoprotein(a)(Lp(A)) and the coronary heart diseases(CHD), the quantitative techniques of meta-analysis were applied to studios of blood lipids and CHD in Koreans. Methods : We searched the Korean and the English literature published from 1980 to August, 1997 by manual search and bibliography review. Information on sample size, study design, participant characteristics(gender, age) and blood lipid levels were abstracted by reviewers using inclusion criteria. Estimates of the effect sizes of blood lipid levels on CHD in Koreans and corresponding 95% confidence intervals were calculated using random-effect models. Results : We identified 16 case-control studies to apply meta-analysis. The overall effect sizes for CHD were 20.3(95% CI: 14.23-20.22) in TC, 24.8(95% CI: 12.6-36.86) in TG, 15.16(95% CI: 3.99-26.33) in LDL, -3.48(95% CI: -5.79 - -1.17) in HDL, -9.78(95% CI: -16.98 - -2.58) in Apo-a1, 17.88(95% CI: 9.72-26.05) in Apo B and 18.95(95% CI: 17.88-20.02) in Lp(a). Conclusions : Our results suggested that seven blood lipids were significantly associated with CHD in Koreans. Well-designed and prospective studies between blood lipids and CMD in Koreans should be peformed.

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