Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Dissemination of Borrelia burgdorferi and immunological responses after experimental infection in rabbits

실험적으로 감염시킨 토끼에서 Borrelia burgdorferi 분포 및 면역반응 양상

  • Kim, Jong-bae (Department of Medical Technology, College of Health Science, Yonsei University) ;
  • Park, Sung-un (Department of Medical Technology, College of Health Science, Yonsei University) ;
  • Song, Hye-wone (Department of Medical Technology, College of Health Science, Yonsei University) ;
  • Park, Sang-wook (Department of Medical Technology, College of Health Science, Yonsei University) ;
  • Kim, Young-mi (Department of Medical Technology, College of Health Science, Yonsei University)
  • 김종배 (연세대학교 보건과학대학 임상병리학과) ;
  • 박성언 (연세대학교 보건과학대학 임상병리학과) ;
  • 송혜원 (연세대학교 보건과학대학 임상병리학과) ;
  • 박상욱 (연세대학교 보건과학대학 임상병리학과) ;
  • 김영미 (연세대학교 보건과학대학 임상병리학과)
  • Received : 1998.10.07
  • Published : 1999.03.22
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Abstract

The visceral dissemination of Borrelia burgdorferi in New Zealand White rabbits was evaluated following intradermal inoculation of $1{\times}10^8$ spirochetes. We inoculated Borrelia burgdorferi B31, B garinii KW1 and B afzehlii S13, respectively, and monitored the dissemination in the experimentally infected rabbits for 28 days. In the B burgdorferi B31-challenged group, the spirochetes were completely cleared in rabbits at day 1 and visceral dissemination was not demonstrated. However, B garinii KW1 and B afzelii S13 were found to successfully disseminate in visceral organs of rabbits during the experiment period of 28 days. And experimentally infection-derived immunological responses in rabbits were identified with enzyme-linked immunosorbent assay and immunoblot analysis. Based on these results, the differences in the virulence of Lyme borrelial strains were proved in rabbit model.

Keywords

Acknowledgement

Supported by : 한국학술진흥재단