Journal of Periodontal and Implant Science
- Volume 29 Issue 4
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- Pages.725-737
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- 1999
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
Effects of Several Biodegradable Controlled-Release Local Delivery Drugs on the Treatment of Periodontitis
수 종의 생분해성 국소약물 송달제제가 치주염 치료에 미치는 효과
- Yang, Dae-Seung (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- You, Kyung-Tae (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Pi, Sung-Hee (Department of Periodontology, School of Dentistry, Wonkwang University) ;
- Lee, Myung-Yeon (Department of Periodontology, School of Dentistry, Wonkwang University) ;
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You, Yong-Ouk
(Department of Oral Biochemistry, College of Dentistry, Seoul National University) ;
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You, Hyung-Keun
(Department of Periodontology, School of Dentistry, Wonkwang University) ;
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Shin, Hyung-Shik
(Department of Periodontology, School of Dentistry, Wonkwang University)
- 양대승 (원광대학교 치과대학 치주과학교실) ;
- 유경태 (원광대학교 치과대학 치주과학교실) ;
- 피성희 (원광대학교 치과대학 치주과학교실) ;
- 이명연 (원광대학교 치과대학 치주과학교실) ;
-
유용욱
(서울대학교 치과대학 구강생화학교실) ;
-
유형근
(원광대학교 치과대학 치주과학교실) ;
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신형식
(원광대학교 치과대학 치주과학교실)
- Published : 1999.12.31
Abstract
The present study was performed to evaluate the clinical effects following local application of 30% minocycline strip(polycaprolactone), 2% minocycline gel(hydrocarbon gel) and 12% minocycline strip(polylactide, Minodent) to augment scaling and root planing in patients with chronic adult periodontitis. Forty teeth with periodontitis were enrolled in the study anddistributed into 4 groups including control group. All patients performed standardized oral hygiene instructions and mechanical debridement at the beginning of the study and then each local delivery drugs were inserted into periodontal pocket in each groups. Examinations regarding plaque index(PI), papillary bleeding index (PBI), probing pocket depth (PPD) were carried out at 0, 2, 4 weeks. All experimental groups showed statistically significant differences between baseline and 2 and 4 weeks in every clinical indices. Especially, 30%minocycline strip and Minodent group showed a significant improvement in PBI at 2 weeks and in PPD at 2 and 4 weeks. In conclusion, highly bio-resorbable Minodent delivered subgingivally as an adjunct to scaling and root planing induces better clinical effects for periodontal health than 2% minocycline gel and control group.
Keywords