Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Tissue Engineering with rhBMP-2;Bone Reconstruction in Implant Dentistry

rhBMP-2를 이용한 조직공학;치과 임프란트에서의 골 재건

  • Wikesj, Ulf ME. (Temple University School of Dentistry, Department of Periodontology Director, Postgraduate Specialty Program in Periodontology Director, Laboratory for Applied Periodontal and Craniofacial Regeneration Diplomate, American Board of Periodontology) ;
  • Hanisch, Oliver (University of Aachen Medical Center, Department of Prosthodontics Visiting Assistant Professor Temple University School of Dentistry, Department of Periodontology Research Fellow, Laboratory for Applied Periodontal & Craniofacial Regeneration) ;
  • Danesh-Meyer, Michael J. (Temple University School of Dentistry, Department of Periodontology Director, Postgraduate Specialty Program in Periodontology Director, Laboratory for Applied Periodontal and Craniofacial Regeneration Diplomate, American Board of Periodontology) ;
  • Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Research Institute for Periodontal Regeneration, Yonsei University) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Research Institute for Periodontal Regeneration, Yonsei University)
  • Published : 1999.09.30
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Abstract

The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to non-space providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.

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