대한세포병리학회지 (The Korean Journal of Cytopathology)
- 제10권1호
- /
- Pages.79-84
- /
- 1999
- /
- 1017-0391(pISSN)
간의 파골세포모양 거대세포 종양의 세침흡인 세포학적 소견
Fine Needle Aspiration Cytology of Osteoclast-like Giant Cell Tumor of the Liver
- Park, Chan-Sik (Department of Pathology, Seoul National University, College of Medicine) ;
- Kim, Ji-Eun (Seoul Municipal Boramae Hospital Affiliated to Seoul National University Hospital) ;
- Chang, Mee-Soo (Seoul Municipal Boramae Hospital Affiliated to Seoul National University Hospital)
- 발행 : 1999.06.30
초록
Osteoclast-like giant cell tumor of the liver is an extremely rare malignancy with poor prognosis. To our knowledge, 5 cases have been reported in English literatures, but there was no report about fine needle aspiration cytologic(FNAC) features. We experienced a case of osteoclast-like giant cell tumor of the liver obtained by computed tomography(CT)-guided FNAC and needle biopsy. The cytologic findings mimicked slant cell tumor of the bone. A large hepatic mass of the left lobe with abdominal wall invasion was found by CT in a 46- year-old female complaining of epigastric pain. The FNAC showed moderately cellular smears consisting of osteoclast-like giant cells and mononuclear cells, which were individually scattered or intermingled in clusters. The osteoclast-like giant cells had abundant cytoplasms and multiple small round nuclei with fine chromatin and distinct nucleoli. The mononuclear cells had moderate amount of cytoplasm and relatively bland-looking oval nuclei with single small nucleoli. All of the cytologic features recapitulated the histologic findings of bland-looking osteoclast-like multinucleated giant cells evenly dispersed throughout the background of mononuclear cell. The immunohistochemical study showed positive reaction for CD68 and vimentin, but negative for cytokeratin in both osteoclast-like slant cells and mononuclear cells.