Journal of Environmental Health Sciences (한국환경보건학회지)
- Volume 25 Issue 3
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- Pages.58-63
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- 1999
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- 1738-4087(pISSN)
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- 2233-8616(eISSN)
Application of Rats According to Molecular Weight of Chitosan
키토산의 분자량에 따른 랫드에서의 적용
- Jung, Duck-Chae (Department of Chemistry, University of InChon) ;
- Lee, Ki-Chang (Department of Chemical Engineering, MyongJi University) ;
- Yoon, Cheol-Hun (Department of Chemical Engineering, MyongJi University) ;
-
Kim, Pan-Gyi
(Department of Environmental Health, Yong In University) ;
- Shin, Dong-Hwan (Division of Hematopathology, NITR, KFDA)
- 정덕채 (인천대학교 화학과) ;
- 이기창 (명지대학교 화학공학과) ;
- 윤철훈 (명지대학교 화학공학과) ;
-
김판기
(용인대학교 환경보건학과) ;
- 신동환 (식품의약품안전청 국립독성연구소 혈액병리과)
- Published : 1999.09.01
Abstract
Biodegradable films were prepared by solution blend method in the weight ratio of chitosan for the purpose of useful biomaterials. The possibility of biomaterials prepared from natural polymer as a skin substitute was evaluated by measuring biocompatibility. These films were inserts in the back of rat and their biodegradability was investigated by the film weight and hematology as a function of time for the biotransformation. The result of rat test showed that medium, high viscosity chitosan induced some suspects of inbiocompatibility in the tissue by goreign body reaction 48 and 72 hours after implantation. Also, we prepared the official burn ointment which is made by low viscosity chitosan. This burn ointment was covered on the skin wound of artificial burn and their effect of healing was investigated by the evaluation of the naked eye and hematological change as a function of time. The result of rats test showed that burn ointments made from chitosan was effective reductio of inflammation than negative group.