Korean Journal of Bronchoesophagology (대한기관식도과학회지)

The Korean Bronchoesophagological Society (대한기관식도과학회)
권호 표지

The Modulation of Squamous Cell Differentiation by Retinoids in Human Squamous Cell Carcinoma Xenografts

Nude Mouse 에 이종이식한 두경부 편평상피세포암의 분화에 대한 Retinoids의 작용

  • Kim, Sang-Yoon (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine) ;
  • Yoo, Seung-Joo (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine) ;
  • Yoo, Keun-Sik (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine) ;
  • Joo, Joon-Bum (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine) ;
  • Choi, Doo-Yung (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine) ;
  • Nam, Soon-Yuhl (Department of Otolaryngology, Asan Medical Center,University of Ulsan College of Medicine)
  • 김상윤 (울산대학교 의과대학 서울중앙병원 이비인후과학교실) ;
  • 유증주 (울산대학교 의과대학 서울중앙병원 이비인후과학교실) ;
  • 유근식 (울산대학교 의과대학 서울중앙병원 이비인후과학교실) ;
  • 주준범 (울산대학교 의과대학 서울중앙병원 이비인후과학교실) ;
  • 최두영 (울산대학교 의과대학 서울중앙병원 이비인후과학교실) ;
  • 남순열 (울산대학교 의과대학 서울중앙병원 이비인후과학교실)
  • Published : 1999.12.01
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Abstract

Objectives : To analyze the effect of retinoids on the differentiation in HNSCC xenografts. Materials and Methods : RA (20mg/kg) or 13-cis-RA (60mg/kg) was orally administered once in a day for 30 days in the xenograft model we prepared using athymic nude mice with AMCHN-4 and -6. We carried out H & E staining and immunohistochemical staining with the monoclonal antibody against involucrin and cytokeratin 10. Results : Both RA and 13-cis-RA were found to suppress the differentiation of AMC-HN-4. Interestingly, RA enhanced the differentiation of AMC-HN-6, although 13-cis RA did not exhibit any effect on the differentiation. These results suggest that in vivo effect of retinoids on the HNSCC growth and differentiation might be various. Retinoids-induced P450 in AMC-HN-6 might be one of the mechanisms to explain the reason why the retinoids exhibit various functions in the HNSCC.

Keywords