대한바이러스학회지 (The Journal of Korean Society of Virology)
- 제29권4호
- /
- Pages.283-288
- /
- 1999
- /
- 1225-2344(pISSN)
Development of Zosteriform Models in Skin and Vagina of Mice using Herpes simplex Virus Strain McKrae
-
Lee, Hyung-Hoan
(Department of Biological Science, Konkuk University) ;
- Cha, Soung-Chul (Department of Biological Science, Konkuk University) ;
- Uh, Hong-Sun (Department of Biological Science, Konkuk University) ;
- Cho, Jae-Kyung (Department of Biological Science, Konkuk University) ;
- Lee, Jun-Keun (Department of Biological Science, Konkuk University) ;
- Chang, Dong-Jun (Department of Biological Science, Konkuk University) ;
-
Kim, Soo-Young
(Department of Biological Science, Konkuk University)
- 발행 : 1999.12.30
초록
Zosteriform lesions, occurring after left flank and intravaginal inoculations of Balb/c mice with the Herpes simplex virus type 1 strain McKrae, developed in clinically normal skin via nerve endings. The developments of zosteriforms were standardized in 5 phases with the following references; formation of small vesicles (phase 1); occurrence of erosion and ulceration of local lesions (phase 2); occurrence of ulcerations (phase 3); occurrence of severe ulcerations (phase 4); and death (phase 5). These results provide two valuable zosteriform models to further investigate and analyze the pathological symptoms in susceptible animals infected with HSV-1 or HSV-2 and DNA vaccines.