The Preventive Effect of Systemic Treatment with Interferon-${\alpha}2B$ for Infertility of Mumps Orchitis

유행성 이하선염성 고환염 환자의 불임에 대한 Interferon ${\alpha}$-2B의 예방 효과

  • Ku, Ja-Hyeon (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Yim, Yong-Soon (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Lee, Chang-Ho (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Kim, Young-Ho (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Song, Yun-Seob (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Jeon, Youn-Soo (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Kim, Min-Eui (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Lee, Nam-Kyu (Department of Urology, School of Medicine, Soonchunhyang University) ;
  • Park, Young-Ho (Department of Urology, School of Medicine, Soonchunhyang University)
  • 구자현 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 임용순 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 이창호 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 김영호 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 송윤섭 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 전윤수 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 김민의 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 이남규 (순천향대학교 의과대학 비뇨기과학교실) ;
  • 박영호 (순천향대학교 의과대학 비뇨기과학교실)
  • Published : 1999.03.30

Abstract

Postpubertal mumps may result in ochitis and permanent testicular atrophy may develop following infection. This present study was initiated to evaluate the preventive effect of interferon-${\alpha}2B$ on infertilty after mumps orchitis. There were 21 patients with mumps orchitis between May 1990 and June 1997. Patients were randomly distributed into 2 groups: group 1 patients (n=13) maintained therapy with interferon-${\alpha}2B$ ($3{\times}10^6$ IU per day) and group 2 were managed by conservatively. All of the patients were evaluated with testis size measurement, mumps virus titer, hormone level, and if possible semen analysis. For group 1 patients symptoms disappeared within 2 to 3 days and the volume of testis returned to normal within 11 days and testis atrophy was not observed in all patients in follow up. But asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). For group 2 patients symptoms disappeared within 5 to 6 days and the volume of testis returned to normal within 10 days and testis atrophy was observed in 3 patients (unilateral 2, bilateral 1) in floow up. Asthenospermia was continued in 4 patients (unilateral 2, bilateral 2). Sperm count and morphology were recovered all the recover in group 1, 4 patients had persistent reduced sperm count and morphology in group 2, respectively. These observations suggest that systemic interferon-${\alpha}2B$ treatment is highly effective in preventing infertilty as well as testicular atrophy after mumps orchitis.

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