한국군사과학기술학회지 (Journal of the Korea Institute of Military Science and Technology)
- 제2권1호
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- Pages.73-81
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- 1999
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- 1598-9127(pISSN)
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- 2636-0640(eISSN)
Bis-IBA 유도체의 합성 및 신경작용제 가수분해 촉매 효과 연구
A Study on the Synthesis of bis-IBA Derivatives and their Catalytic Effects on the Hydrolysis Reaction of Nerve Agents
초록
Four bis-iodosobenzoic acid derivatives have been synthesizd in 5 steps following literature methods from 5-hydroxyantranilic acid; 1) diazotization and iodination, 2) acid protection, 3) tosylate substitution, 4) acid deprotection, 5) oxidation of iodo-substituent to iodoso group. Catalytic effects of new 5,5'-tri-, tetra-, deca-, polyethyleneglycoxy- bis(2-iodosobenzoic acid) on hydrolysis reactions of PNPDPP(p-nitrophenyl diphenyl phosphate), sarin and soman have been measured to determine the role of ethyleneglycoxy substituents as phase transfer catalysts. At
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