Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Effects of Continuous Administration of Propofol in Dogs

개에서 Propofol의 연속투여효과

  • Published : 1999.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of continuous administration of propofol on the blood, liver and kidney of dogs were evaluated. Propofol(5mg/kg) was repeatedly administered to 8 mongrel dogs intravenously for consecutive seven days. Time to recovery, body temperature, heart rate, and respiratory rate were measured and recorded during experimental period. Hematology (WBC, RBC, PCV) and serum chemistry (AST, ALT, BUN, Creatinine) were also monitored for eight days. Time to standing significantly decreased on day 4 and 6 compared with that on day 1. Body temperature 5 minutes after injection on day 5 and 6, and respiratory rate before injection on day 2, 3, 5 and 6 were significantly increased, respectively. No significant changes were observed in total WBC counts, total RBC counts and PCV values. The AST and AIT values were decreased on day 2 compared with those on day 1, but were within clinically normal range. There were no significant changes in BUN and Creatinine levels. This study suggests that consecutive day propofol anesthesia in dogs can be used for the purpose of the treatment and restraint.

Keywords

References

  1. Vet Surg v.24 The effects of consecutive day propofol anesthesia on feline red blood cell Andress,J.L.;Day,T.K.;Day,D.G.
  2. Anaesthesiology v.71 Propofol a new intravenous anaesthetic Biebuyck,J.F.;Phil,D.
  3. Acta Vet Scand v.37 Comparative responses to propofol anaesthesia alone and with α₂-adrenergic medications in a canine model Bufalari,A.;Short,C.E.;Giannoni,C.;Vainio,O.
  4. Br J Anaesth v.60 Haemodynamic changes during anaesthesia induced and maintained with propofol Claeys,M.A.;Gepts,E.;Camu,F.
  5. Postgrad Med J v.61 Propofol by intravenous infusion with nitrous oxide: Dose requierments and haemodynamic effects Coates,D.P.;Prys-Roberts,C.;Speline,K.R.;Monk,C.R.;Norley,I.
  6. Anaesth Analg v.66 Hemodynamic effects of infusion of the emulsion formation of propofol during nitrous oxide anaesthesia in humans Coates,D.P.;Monk,C.R.;Prys-Roberts,C.;Turtle,M.J.
  7. J Vet Anaesth v.18 Excitatory phenomena following the use of propofol in dogs Davis,C.
  8. Brit Med J v.280 Suspected anaphylactic reaction to cremophor EL Dye,D.;Walkins,J.
  9. Br J Anaesth v.56 Pharmacology of an emulsion formulation of ICI 35 868 Glen,J.B.;Hunter,S.C.
  10. Br J Anaesth v.59 Some ventilatory effects of propofol as sole anaesthetic agent Goodman,N.W.;Black,A.M.S.;Carter,J.A.
  11. J Sm Anim Pract v.28 A clinical trial of propofol infusion anaesthesia in dogs Hall,L.W.;Chambers,J.P.
  12. Anaesthesia v.43 Effects of thiopentone, etomidate and propofol on the haemodynamic response to tracheal intubation Harris,C.E.;Murray,A.M.;Anderson,J.M.;Grounds,R.M.;Morgan,M.
  13. Brit J Anaesth v.67 Pain on injection of propofol: effects of concentration and diluent Klement,W.;Arndt,J.O.
  14. Drugs v.35 Propofol. A review of its pharmacokinetic properties and use as an intravenous anaesthetic Langley,M.S.;Heel,R.C.
  15. Anaesthesia v.42 Propofol for intravenous sedation MacKenzie,N.;Grant,I.S.
  16. Brit J Anaesth v.53 A study of three doses of ICI 35 868 for induction and maintenance of anesthesia Major,E.;Vemiquet,A.J.W.;Waddel,T.K.;Savege,T.M.;Hoffler,D.E.;Aveling,W.A.
  17. Vet Surg v.24 Evaluation of propofol as a general anesthetic for horses Mama,K.R.;Steffey,E.P.;Pascoe,P.J.
  18. Xenobiotica v.19 Propofol: Assay and regional mass balance in the sheep Mather,L.E.;Selby,D.G.;Runciman,W.B.;McLean,C.F.
  19. Br J Anaesth v.59 Haemodynamic effects of a prolonged infusion of propofol as a supplement to nitrous oxide anaesthesia Monk,C.R.;Coates,D.P.;Prys-Roberts,C.;Turtle,M.J.;Speline,K.R.
  20. Postgrad Med J v.61 The induction of anaesthesia with propofol compared in normal and renal failure patients Morcos,W.E.;Payne,J.P.
  21. Vet Rec v.124 Clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs Morgan,D.W.T.;Legge,K.
  22. Am J Vet Res v.59 Cardiorespiratory and anesthetic effects of propofol and thiopental in dogs Quandt,J.E.;Robinson,E.P.;Rivers,W.J.;Raffe,M.R.
  23. Am J Vet Res v.53 Cardiopulmonary, anesthetic, and postane-sthetic effects of intravenous infusions of propofol in greyhounds and nongreyhounds Robertson,S.A.;Johnson,S.;Beemsterboer,J.
  24. Postgrad Med J v.61 Changes in liver function after propofol ('Diprivan') Robinson,F.P.;Patterson,C.C.
  25. Anesthesiology v.71 Propofol: a new intravenous anesthetic Sebel,P.S.;Lowdon,J.D.
  26. Xenobiotica v.21 Species differences in blood profiles, metabolism and excretion of 14C-propofol after intravenous dosing to rat, dog and rabbit Simons,P.J.;Cockshott,I.D.;Douglas,E.J.;Gordon,E.A.;Knott,S.;Ruane,R.J.
  27. J Am Vet Med Assoc v.202 Adverse effects of administration of propofol with various preanesthetic regimens in dogs Smith,J.A.;Gaynor,J.S.;Bednarski,R.M.;Muri,W.W.
  28. Postgrad Med J v.61 A review of the safety and tolerance of propofol('Diprivan') Stark,R.D.;Binks,S.M.;Dutka,V.N.;O'Connor,K.M.;Arnstein,M.J.A.;Glen,J.B.
  29. Vet Rec v.120 Propofol as an intravenous anaesthetic agent in dogs Watkins,S.B.;Hall,L.W.;Clarke,K.W.
  30. Vet Rec v.126 Induction of an-aesthesia in dogs and cats with propofol Weaver,B.M.O.;Raptopoulos,D.
  31. Am J Vet Res v.54 Pharmacokinetics of propofol in mixed-breed dogs and greyhounds Zoran,D.L.;Riedesel,D.H.;Dyer,D.C.
  32. 한국임상수의학회지 v.16 개에서 Xylazine 전투여가 propofol 마취에 미치는 영향 김지완;장인호