Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Studies on the Concentrations of K, Na and Reduced Glutathione in Red Blood Cells of Jindo Dogs

진도견의 적혈구내 K, Na 및 reduced glutathione 함량에 관한 조사

  • 김홍태 (경북대학교 수의과대학) ;
  • 장혜석 (경북대학교 수의과대학) ;
  • 장우석 (경북대학교 수의과대학) ;
  • 진태원 (경북대학교 수의과대학) ;
  • 장인호 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학) ;
  • 김영홍 (경북대학교 수의과대학) ;
  • ;
  • Published : 1999.12.01
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Abstract

Generally, it is known that the composition of the cation of the dog's RBCs is high in potassium(K) and low in sodium(Na). However, it is reported that certain kinds of dogs have HK, HG phenotype which contains a large amount of reduced glutathione(GSH) by the effect of Na-K pump on the cell membrane of RBC with high concentration of K and low concentration of Na. Although this HK phenotype is not regarded as a disease, it is supposed to be an important assignment to examine the distribution and the occurrence rate of the dogs that contain HK cell in their RBCs for the proper clinical treatments as these HK dogs are very sensitive to aromatic disul-fide or onions and have a tendency to cause hemolysis. Accordingly, present study was performed to measure the concentration of K, Na and GSH in the RBCs of Jindo dogs and that of Dosa dogs at the same time.

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References

  1. J. Lab. Clin. Med. v.61 Improved method for the determination of blood glutathione Beutler,E.;Dulon,O.;Kelly,B.M.
  2. Biochim. Biophys. Acta. v.79 Species differences in the effect of sodium Chan,P.C.;Calabrese,V.;Theil,L.S.
  3. Br. J. Haematol. v.50 Erythrocytehemighosts; A hall mark of severe oxidative injury in vivo Chan,T.K.;Chan,W.C.;Weed,R.I.
  4. Journal of the American Veterinary Medical Association v.190 Pseudohyperkalemia in Akitas Degen,M.
  5. Blood v.65 Glutathione-dependentprotection against oxidative damage of the humans red cell membrance Fujise,H.;Dale,G.L.;Beutler,E.
  6. Biochim. Biophys. Acta. v.1239 Na-depen-dent glutamate transport in high glutathione (HK/HG)and high K and high glutathione (HK/HG) and high K and low glutathione (HK/LG) dog red blood cells Fujise,H.;Hamada,Y.;Mori,M.;Ochiai,H.
  7. Experimental Animal v.46 Heredity of Red Blood Cells with High K and Low Glutathione (HK/LG) and High Glutathione (HK/HG) in a Family of Japanese Shiba Dogs Fujise,H.;Hishiyama,N.;Ochiai,H.
  8. J. Physiol. v.405 Na -K pump activities of high and low potassium sheep red cells with internal magnesium and calcium altered by A23187 Fujise,H.;Larf,P.K.
  9. Am. J. Vet. Res. v.54 Variant of canine erythrocytes with high potassium content and lack of glutathione accumulation Fujise,H.;Mori,M.;Ogawa,E.;Maede,Y.
  10. Am. J. Physiol. v.260 Several cation transporters and volum regulation in high-K dog red blood cells Fujise,H.;Yamada,I.;Masuda,M.;Miyazawa,Y.;Ogawa,E.;Takahashi,R.
  11. J Biol Chem v.259 Increase of Na gradient-dependent L-glutamate and L-aspartate transport in high K dog erythrocytes associated with high activity of (Na,K)- ATPase Inaba,M.;Maede,Y.
  12. Jap. J. vet. Res. v.35 The hemolytic effect of onions on canine erythrocytes associated with inherited high Na,K-ATPase activity Kobayashi,K.
  13. Am. J. Vet. Res. v.48 Energy metabolism in canine erythrocytes associated with inherited high Na and K stimulated adenisine triphosphatase activity Maede,Y.
  14. Jap. J. vet. Sci. v.39 High concentration of blood glutathione in dogs with acute hemolytic anemia Maede,Y.
  15. Res. Vet. Sci. v.50 Hereditary high-potassium erythroctes with high Na, K-ATPase activity in JapaneseShiba Dogs Maede,Y.;Amano,Y.;Nishida,A.;Murase,T.;Sasaki,A.;Inaba,M.
  16. J. Biol. Chem v.260 (Na,K)-ATPase and ouabain binding in reticulocytes from dogs with high K and low K erythrocytes and their changes during matu-ration Maede,Y.;Inabe,M.
  17. Blood v.61 Increase of Na-K-ATPase activity, glutamate, and aspartate uptake in dog erythrocytes associated with hereditary high accumulation of GSH, glutamate, glutamine and aspartate Maede,Y.;Inaba,M.;Taniguchi,N.
  18. Blood v.59 Hereditary high concentration of glutathione in canine erythrocytes associated with high accumulation of glutamate, glutamine and aspartate Maede,Y.;Kasai,N.;Taniguchi,N.
  19. Blood v.73 Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic disulfide Maede,Y.;Kuwabara,M.;Sasaki,A.;Inaba,M.;Hiraoka,W.
  20. Blood v.61 Red blood cell glucose metabolism in trisomy 10p: possible role of hexokinase in the erythrocyte Magnani,M.;Stocchi,V.;Piatti,E.
  21. J. Biochem. v.59 Studies on erythrocyte glycolysis. Ⅱ. Free energy changes and rate-limiting steps in erythocyte glycolysis Minakami,S.;Yoshikawa,H.
  22. Nature v.194 A direct relationship between adenosine triphosphate level and in vivo viability of erythrocytes Nakao,K.;Wada,T.;Kamiyama,T.
  23. Experimental Animal v.37 A dog possessing high glutathione (GSH) and K concentrations with an increased Na, K-ATPase activity in its eryghrocytes Ogawa,E.;Fujise,H.Kobayashi,K.
  24. J. Physiol. v.354 Sodium and adenosine triphosphate dependent calcium movements in membrane vesicles prepared from dog eryghrocytes Ortiz,O.E.;Sjodin,R.A.
  25. J. Gen. Physiol. v.62 Dog red blood cells : adjustment of salt and water content in vitro Parker,J.C.
  26. J. Clin. Invest v.46 Erythrocyte energy metabolism in hereditary spherocytosis Reed,C.F.;Young,L.E.
  27. Am. J. Vet. Res. v.53 Susceptibility to onion-induced hemolysis in dogs with hereditary high erythrocyte reduced glutathione and potassium concentrations Yamato,O.;Maede,Y.