Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Histopathological Studies on Effect of Dropwort on Cadmium Poisoning in Mice

미나리가 마우스의 카드뮴 중독에 미치는 병리조직학적 관찰

  • Published : 1999.06.01
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Abstract

This study was undertaken to find out the effect of dropwort on histopathological changes of cadmium toxicity in mice. Thirty two mice of BALB/c strain were divided into a control group (A) and three experimental groups (B, C, D). Each group was consisted of four males and four females : group A received tap water and basal diet, group B received tap water and diet supplemented with 100 mg/kg of cadmium, group C received dropwort juice and diet supplemented with 100 mg/kg of cadmium, group D received dropwort juice and basal diet. All mice were dissected on the 35th day. Pathological changes in liver, kidney, spleen, heart, lung, stomach and muscle were observed. Group D showed no significant change as the control group. But group B showed many cytoplasmic vacuoles and necrosis of hepatocytes, glomerular swelling, and degeneration and necrosis of convoluted tubules in kidney, marked congestion and hemorrhage, and a large number of variably sized alveolar macrophages appearance in lung and swelling in some part of muscle fiber. On the other hand, group C showed a little convalescent changes and maintained their normal architectures in liver, kidney, lung and muscle.

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References

  1. Myongji Univ, Graduate Course, Ph D Thesis The protective effect of leek on the cadmium poisoning in rats Ahn,R.H.
  2. Proc Exp Biol Med v.130 Dietary cadmium, iron and zinc interaction in the growing rat Bains,R,J.;Pond,W.J.;Walker,E.F.
  3. Veterinary toxicoloty Bartik,M.;Piscac,A.
  4. Veterinary medicine(6th ed.) Blood,D.C.;Henderson,J.A.;Radostitis,O.M.
  5. J Nutr v.101 Effect of ascorbic acid on cadmium toxicity in the young coturinix Fox,M.R.S.;Fry,B.E.;Schertel,M.E.
  6. AMA Arch Indust Hyg v.5 Futher investigations on chronic poisoning, A study on rabbit with radioactive cadmium Friberg,L.
  7. Arch Environ Health v.28 Renal and skeletal leisons in experimental cadmium poisoning Itokawa,Y.;Abe,T.;Tabei,R.
  8. Korea Univ Med J v.21 no.1 A study on the effect of garlic on toxicity of cadmium in the rats Kim,S.K.
  9. Korea Univ Med J v.21 no.3 The effect of garlic on pathological damages of testis due to cadmium poisoning Lee,H.S.;Bae,E.S.;Cha,C.W.
  10. Korea J Vet Res v.27 The effects of dietary cadmium, zinc, iron and copper concentrations of tissues and hair in rats Lee,K.W.;Lee,H.B.
  11. Arch Environ Health v.25 Cadmium and zinc in pregnancy and lactation Lucis,O.J.;Lucis,R.S.;Shaikn,Z.A.
  12. J Dairy Sci v.58 Metabolism and toxicity of cadmium, mercury and lead in animal Neathery,M.W.;Miller,W.J.
  13. Am J Res v.42 Comparative toxicity of feeding dired urban sludges and an equivalent amount of cadmium to swine Osuna,O.;Edds,G.T.;Popp,J.A.
  14. Am J Physiol v.219 Hypertention and tissue metal levels following intravenous cadmium, mercury and zinc Perry,H.M.;Erlanger,A.;Yunice,S.E.
  15. Acta Pharmacol & Toxicol v.2 Studies on incisor pigmentation in relation on liver, iron and blood picture in white rat. Ⅳ. The relation between cadmium poisoning and iron metabolism Pindborg,E.V.;Pindborg,J.J.;Plum,C.M.
  16. Arch Environ Heath v.12 Proteinuria in chronic cadmium poisoning Piscator,M.
  17. Arch Internat Pharmacodyn v.86 Liver and spleen in haematopoiesis Plum,C.M.
  18. J Nutr v.36 Cadmium induced anemia in growing pig. Protective effect of oral or parental iron Pond,W.G.;Walker,E.F.;Kirtland,D.
  19. J Nutr v.104 Pathological changes produced in Japanese quail by ingestion of cadmium Richardson,M.E.;Fox,M.R.S.;Fry,B.E.
  20. J Chronic Dis v.14 Abnormal trace metals in man, cadmium Schroeder,H.A.;Balassa,J.J.
  21. JAVMA v.177 Public health aspects of toxic heavy metals in animal feeds Sharma,R.P.;Street,J.C.
  22. Clinical and morphologic effects of oral cadmium toxicity in rabbit v.94 Stowe,H.D.;Wilson,M.;Goyer,R.A.
  23. Heavy metal toxicology (printed Japanese) Medical v.21 Tsuchiya,K.
  24. Jap J Ind Health v.16 Perspective in the environmental toxicology Tsuchiya,K.
  25. Trace element in human and animal nutrition(4th ed.) Underwood,E.J.
  26. Arch Environ Health v.30 Bone and kidney leisons in experimental cadmium intoxication Yoshiki,S.;Yanagisawa,T.;Kimura,M.
  27. 韓國植物大寶鑑(資源編) 송주석