An Epithermal Neutron Beam Design for BNCT Using $^2H(d,n)^3He$ Reaction

  • Published : 1999.10.01

Abstract

A feasibility study was performed to design an epithermal neutron beam for BNCT using the neutron of 2.45 MeV on the average produced from $^2H(d,n)^3$He reaction induced by plasma focus in the z-pinch instead of the conventional accelerator-based $^3H(d, n)^4$He neutron generator. Flux and spectrum were analyzed to use these neutrons as the neutron source for BNCT. Neutronic characteristics of several candidate materials in this neutron source were investigated Using MCNP Code, and $^7LiF$ ; 40%Al + 60%$AIF_3$, and Pb Were determined as moderator, filter, and reflector in an epithermal neutron beam design for BNCT, respectively. The skin-skull-brain ellipsoidal phantom, which consists of homogeneous regions of skin-, bone-, or brain-equivalent material, was used in order to assess the dosimetric effect in brain. An epithermal neutron beam design for BNCT was proposed by the repeated work with MCNP runs, and the dosimetric properties (AD, AR, ADDR, and Dose Components) calculated within the phantom showed that the neutron beam designed in this work is effective in tumor therapy. If the neutron source flux is high enough using the z-pinch plasma, BNCT using the neutron source produced from $^2H(d,n)^3$He reaction will be very feasible.

Keywords

References

  1. Neutron Beam Design, Development, and Performance for Neutron Capture Therapy Rapporteurs' Report R.M.Brugger;G.Constantine;O.K.Harling;F.J.Wheeler;O.K.Harling(et al.)(eds.)
  2. Proc. of the Int. Conf. on the Physics of Nuclear Science and Technology Designing an Epithermal Neutron Beam for Boron Neutron Capture Therapy for the Fusion Reactions $^ 2H(d,\;n)^ 3He\;and\;^ 3He(d,\;n)^ 4He$ J.M.Verbeke;S.V.Costes;D.Bleuel;J.Vujic;K.N.Leung
  3. Neutron Beam Design, Development, and Performance for Neutron Capture Therapy Monte Carlo Methods of Neutron Beam Design for Neutron Capture Therapy at the MIT Research Reactor(MITR-Ⅱ) S.D.Clement;J.R.Choi;R.G.Zamenhof;J.C.Yanch;O.K.Harling;O.K.Harling(et al.)(eds.)
  4. Small Plasma Physics Experiments Ⅱ Proc. of Symposium on Small Scale Laboratory Plasma Experiments Technology of a Small Plasma Focus S.Lee
  5. LA-12625-M RSIC Computer Code Collection : MCNP-A General Monte Carlo N-Particle Transport Code, Version 4B J.F.Breismeister(ed.)
  6. Radiat. Res. v.126 A Monte Carlo Investigation of the Dosimetric Properties of Monoenergetic Neutron Beams for Neutron Capture Therapy J.C.Yanch;X.L.Zhou;G.L.Brownell
  7. Accelerator-Based Epithermal Neutron Beam Design for Boron Neutron Capture Therapy(BNCT) J.K.KIM(et al.)
  8. MIRD, J. Nucl. Med. no.SUP.3 Estimates of Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom W.S.Snyder;M.R.Ford;G.G.Warner;H.L.Fisher,Jr.
  9. Nucl. Technol. v.25 Monte Carlo Dosimetry Calculation for Boron Neutron Capture Therapy in the Treatment of Brain Tumors O.L.Deutsch;B.W.Murray
  10. Int. J. Appl. Radiat. Isot. v.33 Kerma Factors of Elements and Compounds for Neutron Energies below 30 MeV R.S.Caswell;J.J.Coyne;M.L.Randolph
  11. Med. Phys. v.2 Boron Neutron Cpture Therapy for the Treatment of Celebral Gliomas; Ⅰ. Theoretical Evaluation of the Efficacy of Various Neutron Beams R.G.Zamenhof;B.W.Murray;G.L.Brownell;G.R.Wellum;E.I.Tolpin
  12. Radiat. Res. v.128 Boron Neutron Capture Therapy of a Murine Melanoma with p-boronophenylalanine: Dose Response Analysis Using a Morbidity Index J.A.Coderre;D.N.Slatkin;P.L.Micca;J.R.Ciallelle