Journal of Photoscience

Korean Society of Photoscience (한국광과학회)
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EFFECTS OF PHOSPHATIDYLETHANOL ON INOSITOL 1,4,5-TRIPHOSPHATE LEVEL OF CULTURED NG108-15 CELLS

  • Chung, In-Kyo (Depatments of Clinical Pharmacology and Maxillofacial Surgery College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Kim, Chun-Do (Departments of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Chung, Yong-Za (Department of Biochemistry, College of Pharmacy, Kyungsung Univeristy) ;
  • Kim, Inn-Se (Departments of Anesthesiology College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Cho, Goon-Jae (Departments of Internal Medicine College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Park, Chang-Hwa (Departments of Neurosurgery College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Kim, Bong-Sun (Departments of Anatomy, College of Medicine and Research Institute for Oral Biotechnology, Pusan National University) ;
  • Jang, Hye-Ock (Department of Oriental Pathology and Prescription, College of Oriental Medicine, Dong-Eui Univerisyt) ;
  • Il Yun (Departments of Dental Pharmacology and Biophysics, College of Dentistry and Research Institute for Oral Biotechnology, Pusan National University)
  • Published : 1999.06.01
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Abstract

Tempting to further understand the molecular mechanism of pharmacological action of ethanol, we evaluated effects of phosphatidylethanol (PET) on inositol 1,4,5-triphosphate (IP3) level and protein kinase C (PKC) activity in cultured NG108-15 cells. PET increased intracellular concentration of IP$_3$. PET incorporation into membranes of NG108-15 cells had no effect on the phosphorylation of the PKC-specific substrate MBP$\_$4-14/, thus indicates that PET does not affect PKC activity in this system.

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References

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