Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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The Stability and Mutagenecity of $\beta$-Sitosterol Glycoside, Antimicrobial Compound from Schima wallichii sp. liukiuensis

Schima wallichii sp. liukiuensis로부터 분리된 $\beta$-Sitosterol Glycoside 항균물질의 안정성 및 돌연변이원성

  • Choi, Myung-Suk (Division of Biotechnology, Forestry Research Institute) ;
  • Shin, Keum (Division of Biotechnology, Forestry Research Institute) ;
  • Rhee, Dong-Kwon (College of Pharmacy, Sungkyunkwan University) ;
  • Kwon, Oh-Woung (Division of Biotechnology, Forestry Research Institute) ;
  • Son, Sung-Ho (Division of Biotechnology, Forestry Research Institute)
  • 최명석 (임업연구원 임목육종부 생물공학과) ;
  • 신금 (임업연구원 임목육종부 생물공학과) ;
  • 이동권 (성균관대학교 약학대학) ;
  • 권오웅 (임업연구원 임목육종부 생물공학과) ;
  • 손성호 (임업연구원 임목육종부 생물공학과)
  • Published : 1999.09.01
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Abstract

Stability of the $\beta$-sitosterol glycoside from Schima wallichii sp. at various physical conditions were investigated, mutagenecity of the steroid saponin was determined by Ames test. When exposed in pH 3 to pH 8, the $\beta$-sitosterol glycoside was stable on antimicrobial activity against yeasts. The antimicrobial activity of the $\beta$-sitosterol glycoside also stable in high temperature, $N_2$, $O_2$ gas and light exposure, and metal ion. Ames test result revealed that $\beta$-sitosterol glycoside did not have any mutagenic activity. These results suggest that the $\beta$-sitosterol glycoside might be a promising candidate as a natural antimicrobial compound.

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