Pharmacological Actions of New Wonbang Woohwangchungsimwon Liquid on Cerebral Ischemia and Central Nervous System

신원방우황청심원액의 뇌허혈 및 중추신경계에 대한 약효

  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 조성익 (서울대학교 천연물과학연구소) ;
  • 김용기 (조선무약(자) 생명과학연구소) ;
  • 신대희 (조선무약(자) 생명과학연구소) ;
  • 박대규 (조선무약(자) 생명과학연구소)
  • Published : 1999.03.01

Abstract

In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Liquid(NSCL) and Wonbang Woohwangchungsimwon Liquid(SCL), the effects of NSCL and SCL on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed a preventive effect of NSCL and SCL treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by NSCL and SCL treatment. In contrast to what was seen with ATP, lipid peroxide were elevated in vehicle-treated ischemic gerbils. This elevation was inhibited by NSCL and SCL treatments. While NSCL and SCL had no effects on the hexobarbital-induced sleeping time, they showed sedative effect in rotarod and spontaneous activity test. NSCL and SCL prevented the seizures induced by electric shock and strychnine, but the effect of NSCL was less than that of SCL. Furthermore, NSCL and SCL showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCL on cerebral ischemia and central nervous system are similar to those of SCL.

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