Total Body Fat Content and its Distribution and Plasma Cholesterol Metabolism in Elderly Women

여자 노인의 체지방량 및 체지방 분포와 혈장 콜레스테롤 대사

  • Published : 1999.09.01

Abstract

This study was performed to investigate the risk factors for coronary heart disease in elderly women. Seventy five elderly women over 65 years of age participated with 35 elderly men over 65 years of age, 40 middle-aged men and 31 middle-aged women as control subjects. The percentage of body fat(34.1 5.6%) in elderly women found to be significantly higher than in other groups and their waist/hip circumference ratio(WHR) was higher than in middle-aged women. The concentrations of plasma total cholesterol and LDL-cholesterol in elderly women were higher than in other groups, TG concentration higher than in middle aged women and HDL-cholesterol % lower than in other groups. Plasma cholesterol ester transfer protein(CETP) activities of elderly women were significantly higher than in middle-aged subjects, but were not different from those of elderly men. Plasma Apolipoprotein(Apo) A-I level in elderly women was higher than in middle-aged men but not different from the other groups. Differences among groups were not great in Lipoprotein (Lp)(a)levels. CETP activities were significantly correlated with age, body fat % total cholesterol, LDL-cholesterol and Lp(a). Therefore, it appears that the increased risk of coronary heart disease in elderly women is due to the increase of body fat, central adipose distribution, serum total cholesterol, LDL-cholesterol and CETP activities.

Keywords

References

  1. NAACO Clin ISSu Perinat Womens Health Nurs v.2 Menopause and cardiovascular disease Philosophe R;Seibel MM
  2. JAMA v.269 National Cholesterol Education Program. Summary of the second report of the National Cholesterol Education Program(NCEP) expert panel on detection, evaluation, and treatment of High Blood Cholesterol in Adults
  3. Arterioscler Thromb v.11 Central adipose distribution is related to coronary atherosclerosis Thompson CJ;Ryu JE;Craven TE;Kahl FR;Crouse JR
  4. J Clin Invest v.72 Impact of obesity on metabolism in men and women: Importance of regional adipose tissue distribution Krotkiewski M;Bjrntorp P;Sjostrom L;Smith U
  5. Int J Ob v.16 Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly Mykkaneb L;Laakso M;Pyoralal K
  6. J Lipid Res v.25 High density lipoprotein metabolism Eisenberg S
  7. J Lipid Res v.34 Plasma cholesteryl ester transfer protein Tall AR
  8. J lipid Res v.27 Plasma lipid transfer proteins Tall AR
  9. Atherosclerosis v.122 Lipoprotein(a) is increased in triglyceride-rich lipoproteins in men with coronary heart disease, but dose not change acutely following oral fat ingestion Hoppichler F;Kraft HG;Sandholzer C;Lechleitner M;Patsch JR;Utermann G
  10. Atherosclerosis v.117 Potential environmental effects on adult lipoprotein(a) levels: results from Swedish twins Hong Y;Dahlen GH;Pedersen N;Heller DA;McClearn GE;De Faire U
  11. SAMJ v.78 Serum lipoprotein(a) levels in normal individuals, those with familial hypercholesterolemia and those with coronary artery disease Hughes JK;Mendelsohn D
  12. Science v.246 The mysteries of lipoprotein(a) Uterman G
  13. J Korean Soc Food Sci Nutr v.25 A study on meal management and nutrient intake of the elderly Hong SM;Choi SY
  14. J East Asian of Dietary Life v.7 A Comparative study on the eating behavior in Inchon: the elderly living in home and the elderly nursing home Lee KJ
  15. J Korean Soc Food Nutr v.20 A survey on the food habit and health of the aged in a middle city Cho YS;Lim HS
  16. Korean J Community Nutr v.1 Nutrition and health status of Korean elderly from low income, urban area and improving effect of meal service on nutritional and health status I. An thropometric measurements and nutrient intakes Son SM;Park YJ;Koo JO;Mo SM;Yoon HY;Sung CJ
  17. Characteristics of life patterns and eating behaviors of the long-lived elderly people in Kyungpook Sung-Ju Kim JH
  18. Korean J Nutr v.31 Comparison of nutritional status and immunocompetence of elderly women in urban and rural area Lee JH;Kim HS
  19. Korean J Nutr v.28 The nutritional status of the female elderly residents in nursing home Song YS;Chung HK;Cho MS
  20. Korean J Community Nutr v.1 Nutritional and health status of Korean elderly from low-income, urban area and improving effect of meal service on nutritional and health status III. The effect of meal service on protein nutrition status and serum lipids Park YJ;Koo JO;Choi KS;Kim SB;Yoon HY;SOn SM
  21. Clin Chem v.18 Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge Friedewald WT;Levy RI;Fredrickson DS
  22. Clinical Chemistry v.33 Cholesteryl ester transfer activity in plasma measured by using solid-phase-bound high density lipoprotein Sparks DL;Frohlich J;Cullis P;Pritchard PH
  23. Korean Biochem J v.25 Reaction of HDL-bound cholesteryl ester transfer protein and a new method for its activity measurement Park YB;Jeung NH;Kim JS;Choi MS
  24. Bri J Nutr v.71 Anthropometric values in an elderly French population Delarue J;Constans T;Malvy D;Pradignac A;Couet C;Lamisse F
  25. Am J Clin Nutr v.51 Assessment of body composition by bioelectrical impedance in a population aged > 60y Deurenberg P;Kooij KVD;Evans P;Hulshof T
  26. Korean J Nutr v.30 Nutritional intake and biochemical status in blood and urine of elderly women: Comparisons among subgroups divided by residence type Cha YS;Sohn HS;Joo EJ
  27. Am J Clin Nutr v.55 Sex-and menopause-associated changes in body-fat distribution Ley CJ;Lees B;Stevenson JC
  28. Korean J nutr v.25 Relationship among body fat distribution, adiposity, fasting serum insulin and lipids in adult female Kim SY;Yoon JS;Cha BG
  29. Clin Sci v.10 Differences in the distribution of subcutaneous fat with sex and maturity Edwards DAW
  30. Circulation v.96 Total, LDL, and HDL cholesterol decrease with age in older men and women. The Rancho Bernardo study 1984-1994 Ferrare A;Barrett CE;Shan J
  31. Arterioscler Thromb Vasc Biol v.16 Distribution and correlates of lipids and lipoproteins in elderly Japanese-American men. The Honolulu Heart Program Burchfiel CM;Abbott RD;Sharp DS;Curb JD;Rodriguez BL;Yano K
  32. Am J Public Health v.86 Age-related changes in total and high-density-lipoprotein cholesterol in elderly Dutch men Weijenberg MP;Feskens EJ;Kromhout D
  33. Cardiology v.83 Lipid profile in the Chinese old-old: comparison with younger age groups and relationship with some cardiovascular risk factors and presence of diseases Woo J;Ho SC;Chan SG;Sham A;Yeun YK;Masarei JL
  34. J Gerontol v.49 High density lipoprotein cholesterol subfractions in older people Ettinger WH;Verdery RB;Wahl PW;Fried LP
  35. Biochem Biology Res Commun v.170 Total deficiency of plasma erozygous for the intron 14 splicing defect Yamashita S;Hui DY;sprecher DL;Matsuzawa Y;Sakai N;tarui S;Kaplan D;Wetterau JR;Harmony JAK
  36. N Engl J Med v.434 Increased high density lipoprotein levels caused by a common cholesteryl-ester transfer protein genemutation Inazu A;Brown ML;Hesler CB;Agellon LB;Koizumi J;Takata K;Maruhama Y;Mabuchi H;Tall AR
  37. Atherosclerosis v.90 Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiency Koizumi J;Inazu A;Yagi K;Koizumi I;Uno Y;Kajinami K;Miyamoto S;Moulin P;Tall AR;Mabuchi H;Takeda R
  38. J Clin Invest v.92 Delayed catabolism of high density lipoprotein apolipoprotein A-I and A-II in human cholesteryl ester transfer protein deficiency Ikewaki K;Rader DJ;Sakamoto T;Nishiwaki M;Wakimoto N;Schaefer JR;Ishikawa T;Fairwell T;Zech LA;Nakamura H;Nagano M;Brewer HB
  39. J Biol Chem v.266 Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice Agellon LB;Walsh A;Hayek T;Moulin P;Jiang XC;Shelanski SA;Breslow JL;Tall AR
  40. J Lipid Res v.34 Plasma cholesteryl ester transfer protein Tall AR
  41. J Lipid Res v.33 Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol Hannuksela M;Marcel YL;Kasaniemi YA;Savolainen MJ
  42. Atherosclerosis v.120 CEPT is a determinant of serum LDL-cholesterol but not HDL-cholesterol in healthy Japanese Kinoshita M;Teramoto T;Shimazu N;Kaneko K;Ohta M;Koike T;Hosogaya S;Yamanaka M
  43. Clin Genet v.44 Serum lipoprotein(a) levels in elderly black and white men in the Charleston Heart Study Knapp RG;Schreiner PJ;Sutherland SE;Keil JE;Gilbert GE;Klein RL;Hames C;Tyroler HA
  44. Riv Eur Sci Med Farmacol v.18 Cardiovascular disease and Lp(a) in the adult population and in the elderly: the Brisighella study Nascetti S;D'addato S;Pascarelli N;Sangiorgi Z;Grippo MC;Gaddi A
  45. Atherosclerosis v.99 Lipoprotein(a) is not associated with coronary heart disease in the elderly: cross-sectional data from the Dubbo study Simons L;Friedlander Y;Simons J;McCallum J
  46. Am J Clin Nutr v.53 Body composition in elderly people: Effect of criterion estimates on predictive equations Baumgartner RN;Heymsfield SB;Lichtman S;Wang J;Pierson RN
  47. Atherosclerosis v.80 Relation of body fat distribution to serum lipids and lipoproteins in elderly women Haarbo J;Hassager C;Riis BJ;Christiansen C