Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Calcium and Iron Loading on Bioavailability of Minerals in Normal and Ca/Fe-deficient Rats

칼슘과 철의 과다섭가 성장기 흰쥐의 체내 무기질 이용성에 미치는 영향

  • Published : 1999.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study examined the effect of excess loading of calcium (Ca)and iron(Fe) on the bioavailability of minerals in both normal and Ca-and Fe-deficient rats. Three-week-old male rats were divided into four groups and fed experimental diets for six weeks, containing either normal (0.5%) or high(1.5%) Ca and normal (35ppm) or high (350ppm)Fe. Likewise, three-week-old male rats were first fed a Ca-and Fe-deficient diet for three weeks, and then fed one of four experimental diets for additional three weeks. In both normal and Ca-and Fe-deficient rats, ca contents of serum, liver, kidney and femur were not significantly affected by dietary Ca and Fe levels. Apparent Ca absorption(%) decreased in rats fed a high Ca diet regardless of dietary Fe levels. Magnesium(Mg) contents of serum, liver and femur significantly decreased in rats fed a high Ca diet. Fe contents of serum and liver significantly increased in rats fed a high-Fe diet, but decreased in rats fed a high Ca diet. Fe content of serum and liver significantly increased in rate fed a high-Fe diet, decreased in rats fed a high-Ca diet. Apparent Fe absorption increased in rats fed a high-Fe diet, and decreased in rats fed a high-Ca diet in Ca-and Fe-deficient rats, but dietary Ca did not seem to affect Fe absorption in normal rats. Phosphorus(P) contents of serum and femur were not significantly affected by dietary Ca and Fe levels in both normal and Ca-and Fe-deficient rats. Serum copper(Cu) decreased in rats fed a high-Fe diet, while serum zinc(Zn) decreased in rats fed a high-Ca diet in normal rats. Cu contents of liver, and Zn contents of serum and liver decreased in rats fed a high-Fe diet in Ca-and Fe-deficient rats. There results suggest that a dietary overload of Ca and Fe in both normal and Ca-and Fe-deficient rats may decrease mineral bioavailability leading to potential health problems.

Keywords

References

  1. Nutr Rew v.52 A review of calcium preparations Levenson DI;Bockman RS
  2. J Am Med Asso v.272 Optimal calcium intake NIH Consensus Statement
  3. Korean J Nutr v.27 no.3 Patterns of vitamin/mineral supplements usage among the middle-aged in Korea Kim SH
  4. Korean J Nutr v.30 no.2 Patterns of vitamin/mineral supplements usage by the elderly in Korea Song BC;Kim MK
  5. European J Clin Nutr v.46 Calcium and iron absorption : machanism of action and nutritional importance Hallberg L;Rassander-Hulthen L;Brune M & Gleerup A
  6. Am J Clin Nutr v.53 Calcium supplementation : Effect on iron absorption Cook JD;Dassenko SA;Whittaker P
  7. J Nutr v.122 Dietary calcium modifies concentrations of lead and other metals and renal calbindin in rats Bodgen JD;Gertner SB;Christakos S;Kemp FW;Yang Z;Katz SR;Chu C
  8. Food Chem Toxic v.32 no.3 Mineral interactions in rats fed AIN-76A diets with excess calcium Shackelford ME;Collins TFX;Black TN;Ames MJ;Sheikh DNS;Chir K;O'Donnell MW
  9. Proc Nutr Societ v.54 Iron-zinc and calcium-Fe interaction in relation to Zn and Fe absorption Fairweather-Tait SJ
  10. Am J Clin Nutr v.61 Fortification of sugar with iron sodium ethylenediaminotetraacetate(FeNaEDTA) improves iron status in semirural Guatemalan populations Viteri FE;Alvarez R;Batres R;Torn B;Pineda O;Meja LA;Sylvi J
  11. Lancet v.346 Iron supplementation : is less better? Cook JD
  12. Lancet v.341 Reversal of developmental delays in iron-deficient anemic infants treated with iron Idjradinata P;Pollitt E
  13. Lancet v.343 Adverse effects of iron supplementation on weight gain of iron-replete young children Idjradinata P;Watkins WE;Pollitt E
  14. Nutr Rev v.53 Possible new developments in community control of iron-deficiency anemia Stephenson LS
  15. N Engl J Med v.319 Body iron stores and the risk of cancer Stevens RG;Jones DY;Micozzi MS;Taylor RP
  16. J Clin Invest v.86 Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload Houglum KM;Filip JL;Witztum and M Chojkier
  17. J Nutr v.115 Oral iron, dietary ligands and zinc absorption Sandstrom B;Davidsson L;Cederblad A;Lonnerdal B
  18. Br J Nutr v.71 Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats Yu S;West C;Beynen A
  19. J Nutr v.117 Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies American Institute of Nutrition
  20. Korean Drug Index 약업신문
  21. J Assoc Off Anal Chem v.66 no.5 Atomic absorption determination of serum copper : Collaborative study Osheim DL
  22. J Assoc Off Anal Chem v.73 no.4 Flame atomic spectrometric determination of serum zinc : Collaborative study Perry DF
  23. J Biol Chem v.66 The coloric determination of phosphorus Fisk CH;Subbarow Y
  24. 16th International congress of nutrition Lesion by over intake of calcium on health and mineral status of rats Kimura M;Matumura K;Hatsuda N;Itokawa Y
  25. J Nutr v.119 Mineral interactions relevant to nutrient requirements O'dell BL
  26. J Clin Invest v.67 Jejunal and ileal adaptation to alteration in dietary calcium : Changes in calcium and magnesium absorption and pathogenic role of parathyroid hormone and 1,25-dihydroxy vitamin D Norman DA;Fordtran JS;Brinkley LJ;Zerwekh JE;Nicar MH;Strowing SM;Pak CYC
  27. Am J Clin Nutr v.63 Magnesium balance in adolescent females consuming a low- or high-calcium diet Andon MB;Ilich JZ;Tzagournis MA;Matkovic V
  28. J Nutr v.122 Interaction of calcium and phosphate decreases ileal magnesium solubility and apparant magnesium absorption in rats Brink EJ;Beynen AC;Dekker PR;Van Berestijn ECH;Van der Meer R
  29. J Korean Societ Food Nutr v.26 Effect of calcium levels on peak bone mass formation in growing rats and on bone metabolism in ovariectomezed rats with different bone mass Lee YS;Park MN;Kim EM
  30. Gastroenterology v.84 Calcium inhibition of inorganic iron absorption in rats Barton JC;Conrad ME;Parmley RT
  31. Br J Nutr v.75 Mechanism underlying the inhibitory effect of high calcium carbonate intake on iron bioavailability from ferrous sulphate in anaemic rats Wienk KJH;Marx JJM;Lemmens AG;Brink EJ;Van Der Meer R;Beynen AC
  32. J Nutr v.112 Effect of dietary Ca and P levels on the utilization of Fe, Cu, Zn by adult males Snedeker SM;Smith SA;Greger JL
  33. Free Radical Biol Med v.14 Hydroxyl radical generation by a light-induced Fenton reaction Van der Zee J;Krootjes BBH;Chignell CF;Dubbelman TMAR;Van Steveninck J
  34. Circulation v.86 High stored iron levels are associated with excess risk of myocardial infarction in Estern Finnish men Salonen JT;Nyyssonen K;Korpela H;Tuomilehto J;Seppanen R;Salonen R