Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Bombyx mori Larvae Extracts on Carbon Tetrachloride-Induced Hepatotoxicity in Mice

사염화탄소에 의해 유발된 생쥐의 간독성에 미치는 누에 추출물의 영향

  • 류강선 (농업과학기술원 잠사곤충부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 김선여 (경희대학교 동서의학 대학원)
  • Published : 1999.08.01
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Abstract

To evaluate the protective effects of extracts of silkworm on carbon tetrachloride-induced hepatotoxicity, serum glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase and lactic dehydrogenase activities, malondialdehydes values and glutathione-S-transferase activity were measured in ICR mice. Extracts of silkworm was administered orally at 30min after the administration of CCl4 Mice were sacrificed at 24h after the administration of extracts of silkworm. The activities of serum aminotransferase and the hepatic content of lipid peroxide after carbon tetrachloride treatment were markedly increased than normal control but those levels were decreased by the treatment of butanol soluble fraction of silkworm methanol extract. Glutathione S-transferase activity was decreased by carbontetrachloride than control, but also inhibited by the treatment of butanol soluble fraction of silkworm methanol extract.

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