Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Effect of Tocopherol and Ascorbate on the Enzyme Activity and Antioxidation in $CCl_4$ Induced Rats

Tocopherol과 Ascorbate 투여가 사염화탄소로 유도한 흰쥐의 효소활성 및 항산화적용에 미치는 영향

  • 하배진 (신라대학교 신소재·생명공학부) ;
  • 이상현 (신라대학교 신소재·생명공학부) ;
  • 하종명 (신라대학교 신소재·생명공학부)
  • Published : 1999.06.01
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Abstract

The enzyme activities and antioxidative of tocopherol and ascorbate were investigated at the levels of liver, kidney homogenates and sera of SD-rats intoxicated with tetrachlorocarbon$CCl_4$. GOT and GPT activities of sera in the $CCl_4$ group were 3, 6 times increased compared to normal group. But they tended to decrease significantly in tocopherol and ascorbate administered group. As for BUN and total cholesterol they were the same. HDL-cholesterol in the $CCl_4$group was 42% decreased compared to normal group. HDL-cholesterol was about 26% increased in the tocopherol group and tocopherol ascorbate group compared to $CCl_4$ group. MDA and SOD activities in the liver and the kidney tissue homogenates were significantly increased in $CCl_4$ group compared to normal group. But they were decreased significantly in the tocopherol group and tocopherol-ascorbate group compared to $CCl_4$ group. In view of this study tocopherol and ascorbated were ascorbate were effective on the detoxication of liver and kidney injury.

Keywords

References

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