A Misfolded Thyroglobulin is Retained by Molecular Chaperones in the Endoplasmic Reticulum

  • Kwon, O-Yu (Department of Readiologic Technology, Taegu Health College) ;
  • Seong, Yeon-Mun (Department of Anatomy and Internal Medicine, College of Medicine, Chungnam National University) ;
  • Shong, Min-Bo (Department of Anatomy and Internal Medicine, College of Medicine, Chungnam National University)
  • Published : 1999.06.01

Abstract

Deficient thyroglobulin is one of the important causes of congenital hypothyroid goiter with a prevalence of -1/40,000 humans. We now demonstrate that in cog/cog mice showing hypothyroidism, four endoplasmic reticulum-molecular chaperones stably bind to thyroglobulin, providing insight into physiologic regulation of endoplasmic reticulum storage diseases.

Keywords