Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Four-Week Oral Toxicity Studies of CJ-50002 (Vibrio Vaccine) in Beagle Dogs

비글개에서 CJ-50002(비브리오백신)의 4주간 경구 반복투여 독성시험

  • 이광훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학교실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학교실) ;
  • 이원우 (서울대학교 수의과대학 공중보건학교실) ;
  • 임종희 (서울대학교 수의과대학 공중보건학교실) ;
  • 정지윤 (서울대학교 수의과대학 공중보건학교실) ;
  • 김달현 (제일제당 종합연구소) ;
  • 이영수 (제일제당 종합연구소) ;
  • 이영순 (서울대학교 수의과대학 공중보건학교실)
  • Published : 1999.03.01
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Abstract

This study was carried out to investigate the four-week oral toxicity of the CH-50002 (Vibril vaccine) in beagle dogs. The beagle dogs were orally administered for 28 days, with dosage of 0.5, 5, 50 mg/kg/day, respectively. Animals treated with CJ-50002(Vibrio Vaccine) did not cause any death and show any clinical signs. There were not significantly different from the control group in urinalysis, ocular examination, hematological, serum biochemical value and histopathological examination. Therefore, CJ-50002(Vibrio Vaccine) was not indicated to have any toxic efent in the beagle dogs, when ti was orally administered below the dosage 50mg/kg/day for rour weeks.

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References

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