Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Effects of Methidathion on Humoral Immune Response in Mice

Methidathion이 체액성 면역 반응에 미치는 영향

  • 정혜주 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 김형수 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 박재현 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 박현애 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 김진호 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 정승태 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 한형미 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 조대현 (식품의약품안전청, 국립독성연구소 독성부) ;
  • 김주일 (식품의약품안전청, 국립독성연구소 독성부)
  • Published : 1999.03.01
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Abstract

The effects of methidathion on humoral immune response were studied in BALB/c mice. 0.5 or 5.0 mg/kg/day methidathion were administered orally for 14 days. The parameters examined to assess apparent toxicity of methidathion included changes of body weight, relative weight of spleen, thymus, sidney and liver, and viable spllenic cell numbers. To evaluate the humoral immune response, thymus, kidney and liver, and viable splenic cell numbers. To evaluate the humoral immune resopnse, the plaque forming cell(PFC) responses sheep the red blood cells (SRBC) and the lovels of serum IgG to hen egg lysozyme (HEL) were determined. No alterations were observed in changes of body weights, relative organ weights and the numbers of viable splenocytes by exposure to any dose of methidathion. At the dose of 0.5mg/kg only PFC response was decreased, whereas both PFC response and the level of serum IgG were decreased significantly at the dose of 5.0 mg/kg. These results indicate that exposure to methidathion may cause sup[pression of humoral immune reponse in mice without overt changed in lymphoid organ weight or viability of splenocytes.

Keywords

References

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