흰쥐를 이용한 에페드린의 약물남용가능성 평가

Evaluation on the Abuse Liability of Ephedrine Using Rats

  • 류승렬 (식품의약품안전청 국립독성연구소) ;
  • 김혜진 (식품의약품안전청 국립독성연구소) ;
  • 홍진태 (식품의약품안전청 국립독성연구소) ;
  • 이종권 (식품의약품안전청 국립독성연구소) ;
  • 이선희 (식품의약품안전청 국립독성연구소) ;
  • 이병무 (성균관대학교 약학대학) ;
  • 김부영 (식품의약품안전청 국립독성연구소)
  • 발행 : 1999.10.01

초록

Abuse liability of ephedrine was investigated by measurement of locomotor activity and self-administration in Sprague-Dawley rats. Locomotor activity was determined in rats treated with 3, 10 and 30 mg/kg ephedrine for 14 days. Self-administration by ephedrine (0.23, 1 and 2.3 mg/kg) was examined in food-trained rats. We also examined effect of dopamine receptor antagonist (spiperone, $30{\;}\mu\textrm{g}/kg$) on the ephedrine-induced response of self-administration. Body weight was not statistically difference between control and ephedrine treatment group, but locomotor activity was dose-dependently increased. Self-administration for ephedrine was decreased in the early response (day 1 and 2) but the response was increased by higher dose of ephedrine. Self-administration was decreased by dopamine receptor antagonist (spiperone). These data showed that ephedrine increased locomotor activity and induced response of self-administration, and the effects of ephedrine were partially related to the dopaminergic system, which suggest the ephedrine may have abuse liability.

키워드

참고문헌

  1. Br. J. Psychiatry v.150 Ephedrine psychosis rediscovered Whitehouse, A. M.;Duncan, J. M.
  2. J. Clin. Pharmacol. v.37 Pharmacokinetics and cardiovascular effects of Ma-Huang in normoten-sive adults White L. M.;Gardner, S.F.;Gurley, B. J.;Marx, M A.;Wang, P.;Esters, M.
  3. Eur. J. Clin. Pharmacol. v.9 The metabolism of (-)-Ephedrine in man Sever, P.S.;Dring, L. G.;Williams, R. T.
  4. Neurology v.43 Stoke associated with ephedrine use Bruno, A.;Nolte, K. B.;Chapin, J.
  5. Med. J. Aust. v.167 Ephedrine abuse causing acute myocardial infraction Cockings, J. G. L.;Brown, M. A.
  6. JAMA v.252 no.14 Toxicity of over-the-counter stimulants Pentel, P.
  7. Am. J. Psychiatry v.152 no.4 Ephedrine induced mania from an herbal diet supplement Capwell, R. R.
  8. Gen. Pharmacol. v.24 no.3 The effect of ephedrine isomers and their oxazolidine on locomotor activity in rats Walker, R. B.;Fitz, L. D.;Williams, L. M.;Linton, H. Jr.;Smith, C.C.
  9. Behavioral neuroscience v.II Intravenous drug self-adminjstration techniques in animals Caine, S. B.;Lintz, R.;Koob, F. F.;Sahgal A. (ed.)
  10. J. Neurosci. Meth v.66 no.1 Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy Richardson, N. R.;Roberts, D. C.
  11. Behavioral neuroscience v.I Intravenous drug self-adminjstration techniques in animals Caine, S. B.;Lintz, R.;Koob, F. F.;Sahgal A. (ed.)
  12. J. Neurosci v.17 no.21 Role of dopamine $D_1$ and $D_2$ receptors in the nucleus accumbens in mediating reward Ikemoto, S.;Glazier, B. S.;Murphy, J. M.;Mcbride, W. J.
  13. Pharmacol. Biochem. Behavior v.47 $D_1$ and $D_2$ dopamine receptor antagonists block caffeine-induced stimulation of locomotor activity in rats Garrett, B. E.;Holtzman, S. G.
  14. Psycho-pharmacology v.135 Effect of (-)-ephedrine on locomotor, feeding and nucleus accumbens dopamine in rats Wellman,P.J.;Miiler,D.K.;Livermore,C.L.;Green,T.A.;Mcmahon,L.R.;Nation,J.R.
  15. Br. J. Pharmac. v.74 Dopamine like property of ephedrine in rat brain Zarrindast, M. R.
  16. 식품의약품안전연보 v.1 중추신경흥분제의 의존성시험법 개발에 관한 연구 이선희;이종권;류승렬;류종훈;김대병;김동구;김부영
  17. Pharmacol. Biochem. Behavior v.60 no.3 Reinforcing effects of caffeine, ephedrine, and their binary combination in rats Briscoe, R. J.;Vanecek, S. A.;Vallett, M.;Baird, T. J.;Holloway, F. A.;Gauvin, D. V.
  18. Pharmacol. Biochem. Behavior v.60 no.3 Discriminative stimulus properties of (-)ephedrine Young, R.;Glennon, R. A.
  19. Pharmacol. Biochem. Behavior v.60 no.2 Training dose and session time as contextual determines of beroin self-administration in rats Martin, T. J.;Smith, J. E.;Dworkin, S. I.
  20. Pharmacol. Biochem. Behavior v.34 Self-administration of phenylpropanolamine(PPA) by rats previously trained to self-administer am-phetamine, Wellman, P. J.;Shelton, K.;schenk, S.
  21. Psychopharmacology v.104 Selective dopamine antagonists reduce nicotine self-administraion Corrigall, W. A.;Coen, K. M.