YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Pharmacological Actions of New Wonbang Woohwangchungsimwon Pill on Cardiovascular System

신원방우황청심원의 심혈관계에 관한 약효

  • 조태순 (성균관대학교 약학대학) ;
  • 이선미 (성균관대학교 약학대학) ;
  • 김낙두 (서울대학교 약학대학) ;
  • 허인회 (중앙대학교 약학대학) ;
  • 안형수 (동덕여자대학교 약학대학) ;
  • 권광일 (충남대학교 약학대학) ;
  • 박석기 (조선무약(자) 생명과학연구소) ;
  • 김상호 (조선무약(자) 생명과학연구소) ;
  • 신대희 (조선무약(자) 생명과학연구소)
  • Published : 1999.04.01
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Abstract

In order to investigate the pharmacologic properties of New Wonbang Woohwangchungsimwon Pill(NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not affect significantly the relaxing effects of NSCH and SCH. NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effects that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA), $V_{max}$ and resting membrane potential (RMP) at low doses, whereas inhibitory the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

Keywords

References

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