YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Astragali Radix extract on the Cell Mediated Immunotoxicity of Zinc Chloride

염화아연의 세포성 면역독성에 미치는 황기 추출물의 효과

  • Published : 1999.02.01
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Abstract

Effects of Astragali Radix extract (AG) on the cell mediated-and nonlpecific immunotoxic responses of zinc chloride (Zn) were studied usign ICR mice. Mice were divided into 4 groups (10 mice/group), and Zn was given to the mice 1 hr after i.p. injection with 0.5g/kg of AG by i.p. injection daily for 10 days at a dose of 25 mg/kg. Immune responses on the responses on the relative weight of thymus, delayed-type hypersensitivity to SRBC (DTH), phagocytic activity and circulating leukocytes were evaluated. Zn treatment decreased body weight gain, the relative weight of thymus, DTH and circulating leukocytes compared with those in controls. AG treatment increased DTH, phagocytic activity and circulating leukocytes compared with those in controls. Combination of AG and Zn increased DTH and circulating leukocytes compared with those in controls, but decreased body weight gain and the relative weight of thymus. These findings indicated that AG decreased immunotoxicity of Zn on the DTH and circulating leukocytes.

Keywords

References

  1. The basic scienc of poisons(5th) Casarett and Doull's toxicology Klaassen, C. D.
  2. J. Nutr. (JEV) v.128 no.4 Methallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation Sullivan, V. K.;Burnett, F. R.;Cousins, R. J.
  3. AM. J. Clin. Nutr. v.51 Zinc toxicity Fosmira, G. J.
  4. Arch. Environ. Health v.8 Food poisoning involving zinc contamination Brown, M. A.;Thom, J. V.;Orth, G. L.
  5. JAMA v.212 Intoxication following ingestion of elemetal zinc Murphy, J. V.
  6. J. Am. Coll. Nutr. v.4 no.1 Interacton of trace elements: Clinical significance Brewer, G. J.;Hill, G. M.;Dick, R. D.;Prasad, A. S.;Cossack, Z. T.
  7. JAMA v.252 Excessive intake of zinc impairs immune responses Chandra, R. K.
  8. Yakhak Hoeji v.36 no.4 Effects of zinc chloride on the immune response in ICR mice Anh, Y. K.;Kim, J. H.;Chae, B. S.;Cha, K. J.
  9. JAMA v.244 Zinc lowers high-density-lipoprotein-cholesterol levels Hooper, P. L.;Visconti, L.;Garry, P. J.;Johnson, G. E.
  10. Nippon Eiseigaku Zasshi v.47 no.6 Effects of exercise in the growing stage in mice and of AStragalus membranaceus on immune functions Sugiura, H.;Nishida, H.;Inaba, R.;Iwata, H.
  11. Mol. Biother. v.4 no.3 phytochemicals potentiate interleukin-2 generated lymphokine-activated killer cell cytotoxicity against murine renal cell carcinoma Wang, Y.;Qian, X. Y.;Hadley, H. R.;Lau, B. H.
  12. Chung Hsi Ⅰ Chieh HoTsa Chih v.10 no.1 F3. a fractionated estract of astragalus membranaceus, potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2 Chu, D.;Sun, Y.;Lin, J.;Wong, W.;Mavligit, G.
  13. Immunopharmacology v.20 no.3 Enhancement of the immune response in mice by Astragalus membranaceus extracts Zhao, K. S.;Manicini, C.;Doria, G.
  14. Chung Hua Nei Ko Tsa Chih v.34 no.10 A study on protein metabolism in nephrotic patients treated with Chinese herbe Li, L.;Yu, H.;Pan, J.
  15. B. Ssordete. Karger Baselip Use of mast cell deficient mice to study host parasite relationships in immuno-deficient animals Ree, N. D.;Crowle, P. K.;Ha, T.
  16. Immunol v.38 Effect of stimulation and blokade of mononuclear phagocyte system on the delayed-footpad reation to SRBC in mice Yoshikai, Y.;Maike, S.;Matsumoto, T.;Nomoto, K.;Takeya, K.
  17. Jpn. J. Med. Sci. Biol. v.28 Cell mediated and humoral immunity in mice Sugimoto, M.;Kojima, A. M.;Yaginuma, K.;Gashira, Y. E.
  18. C. R. Soc. Biol. Paris v.148 Etude quantitative du l'acivite granulopexique du system reticuloentherial chezla souris Biozzi, G.;Benacerraf, B.;Stiffel, C.;Halpern, B. N.
  19. J. Immunol. v.72 Micro methods for the study of proteins and antibiotics Stavistsky, A. b.
  20. Yakhak Hoeji v.40 no.3 Immunobiological studies on doses of methanol extract of Astragali Radix Kim, J. H.;Park, J. S.;Chae, B. S.;Kang, T. W.;Park, C. B.;Ahn, Y. K.
  21. Cytokine(A52) v.8 no.10 Stimulation of human peripheral blood mononuclear cells by zinc related cations Wellinghausen, N,lDriessen, C.;Rink, L.
  22. Am. Rev. Respir. Dis.(426) v.147 no.1 Cytokines in metal fume fever Blanc, P. D.;Boushey, H. A.;Wong, H.;Wintermeyer, S. F.;Bernstein, M. S.
  23. Poult. Sci. (PG3) v.70 no.8 Monokines in growth and development Klasing, K. C.;Johnstone, B. J.
  24. Eur. J. Immunol. (EN5) v.27 no.10 Zinc inhibits interleukin-1-dependent T cell stimulation Wellinghausen, N.;Martin, M.;Rink. L.
  25. Gastroenterology v.94 Zinc-induced copper deficiency Hoffman, H. N.;Phyliky, R. L.;Fleming, C. R.
  26. J. Clin. Lab. Immunol.(J3K) v.25 no.3 Immunotherapy with Chinese medicinal herbs. Ⅱ: Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo Chu, D. T.;Wong, W. L.;Mavligit, G. M.