Archives of Pharmacal Research
- Volume 22 Issue 2
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- Pages.208-212
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Cytotoxic Constituents form the Roots of Anthriscus sylvestris
- Lim, Young-Hee (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Leem, Moon-Jeong (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Shin, Dong-Hyuk (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Chang, Hwan-Bong (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Hong, Seung-Woo (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Moon, Eun-Yi (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Lee, Dug-Keun (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Yoon, Sung-June (R&D Centre, Dong-wha Pharmaceutical Ind. Co., Ltd.) ;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University)
- Published : 1999.04.01
Abstract
Activity-guided fractionation of the roots of Anthriscus sylvestris resulted in the isolated and characterization of five cytotoxic compounds, deoxypodophyllotoxin (1), falcarindiol (2), and angeloyl podophyllotoxin (5) from the hexane soluble fraction and morelensin (3), bursehernin (4) from the choloroform soluble fraction. It is the first report of the occurrence of compound 5 in nature.