YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Renal Denervation and Cromakalim on Central Diuretic Action of Glibenclamide, an ATP-dependent $K^+$ Channel Blocker, in Dogs

ATP-의존성 $K^+$ Channel 차단제인 Glibenclamide의 중추적 이뇨작용에 대한 신장 신경제와의 Cromakalim의 영향

  • Published : 1999.10.01
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Abstract

This study was performed to investigate the effects of renal denervation and cromakalim, a K+ Channel opener, on central diuretic action of glibenclamide, an ATP-dependent K+ Channel blocker, in dog. Diuretic action of glibenclamide administered into the vein was weakened markedly by renal denervation and pretreatment of of cromakalim. Above results suggest that central diuretic action of glibenclamide is mediated by renal nerves and K+ Channel localized in kidney.

Keywords

References

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