YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Safflower-seed on the Fracture Healing in Rat Tibia

홍화씨의 경골골절치유에 미치는 영향

  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 최현진 (식품의약품안전청 국립독성연구소 약리부) ;
  • 정면우 (식품의약품안전청 국립독성연구소 약리부) ;
  • 안미령 (식품의약품안전청 국립독성연구소 약리부) ;
  • 유태무 (식품의약품안전청 국립독성연구소 약리부) ;
  • 류항묵 (식품의약품안전청 국립독성연구소 약리부) ;
  • 양지선 (식품의약품안전청 국립독성연구소 약리부)
  • Published : 1999.08.01
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Abstract

We investigated the effect of safflower-seed on fracture healing of fracture model in rat. Fracture healing was evaluated by examining the degree of wound healing macroscopically, radiography, bone histomorphometry and biochemical examination. After 1, 3, 5, 7 days, the would healing was accelerate in safflower-seed diet group. Radiography does not reveal the difference in fracture healing between two group. After 2 weeks, safflower-seed had a significant, stimulatory effect on external callus formation (p<0.05). But after 4, 6, 8 weeks, no difference was observed between normal and safflower-seed dietgroup in callus size. Urinary hydroxyproline, osteocalcin and total alkaline phosphatase decreased significantly (p<0.05) in safflower-seed treated group at 2 week after tracture.

Keywords

References

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