YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Gomisin N and Wuweizisu C, new Inhibitors for Chitin Systhase II from Schizandra chinensis

오미자에서 분리한 새로운 Chitin Synthase II 저해제인 Gomisin N 과 Wuweizisu C

  • Published : 1999.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

To search for new chitin biosynthesis inhibitors from natural sources, several higher plants were examined the inhibitory activity against chitin synthase IIby enzymatic assay. Among them, the extract of Schizandra chinensis strongly showed the inhibitory activity against chitin synthase II. Gomisin N and wuweizisu C were isolated from Schizandra chinensis and showed $IC_50$ value of $62.4{\;}\mu\textrm{g}/ml$ and $19.2{\;}\mu\textrm{g}/ml$, respectively. Activities of these compounds were more stronger than that of polyxin D. However, gomisin N and wuweizisu C showed weakly antifungal activities against various human pathogens.

Keywords

References

  1. Wall structure and biosynthesis in fungi, in Gooday Gooday, G. W.;Trinci, A. P. J.;Gooday, G. W.(eds);Lioyd, D.(eds);Trinic, A. P. J.(eds)
  2. J. biol. Chem v.248 no.4 Yeast Chitin Synthetase Cabib, E.;Ulane, R.
  3. J. Biol. Chem v.261 no.32 Chitin synthase 2, a Presumptive Participant in Septum Formation in Saccharomyces cerevisiae Sburlati, A.;Cabib, E.
  4. Proc. Natl. Acad. Sci v.85 Chitin synthase 2 is essential for septum formation and cell division in Saccharomyces cerevi-siae Silverman, S. J.;Sburlati, A.;Slater, L.;Cabib, E.
  5. Analytical Biochemistry v.219 The use of divalent cations and pH for the determination of specific yeast chitin synthases Choi, W. J.;Cabib, E.
  6. J. Cell. Biol v.139 no.1 A septin-based hierarchy of proteins required for ocalized deposition of chitin in the S. cerevisiae cell wall DeMarrini, D. J.;Adams, A. E. M.;Fares, H.;Virgilio, C. D.;Valle, G.;Chuang, T. S.;Pringle, J. R.
  7. Eur. J. Biochem v.256 Molecular analysis of Chs3p participation in chitin synthase Ⅲactivity COS, T.;Ford, R.;Trilla, A.;Duran, A.;Cabib, E.;Roncero, C.
  8. Yeast v.13 Characterization of CHS4 (CAL2), a gene of S. cerevisiae involved in chitin biosynthesis and allelic to SKT5 and CSD4 Trilla, J. A.;Cos, T.;Duran, A.;Roncero, C.
  9. cerevisiae. Mol. Cell. Biol v.17 no.5 CHS5, a gene involved in chitin synthesis and mating in S Santos, B.;Duran, A.;Valdivieso, M. H.
  10. Mol. Cell. Biol v.12 CSD2, CSD3, and CSD4, genes required for chitin synthesis in S. cerevisiae : the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis Bulawa, C. E.
  11. Cell v.46 The S. cerevisiae structural gene for chitin synthase is not required for chitin synthesis in vivo Bulawa, C. E.;Slater, M. L.;Cabib, E.;Au-Young, J.;Sburlati, A.;Adair, W. L.;Robbins, P. W.
  12. Microbiology v.144 Regulation of chitin synthesis during dimorphic growth of Candida albicans Munro, C. A.;Schofield, D. A.;Gooday, G. W.;Gow, N. A. R.
  13. 향약(생약)대사전 정보섭;신민교
  14. In vitro and In vivo evaluation of antifungal agents Drouhet, E. B.;Dupont, B.;Improsi, L.;Viviani, M.;Tortorano, A. M.
  15. Antifungal drug. Antibiotics in laboratory medicline Mcginnis, M. R.;Rindail, M. G.;Lorian, V(Eds)
  16. Planta Medica v.50 Antihepatotoxic actions of lignoids from Shizandra chinensis Fruits Hiroshi, H.;Yoshinobu, K.;Heihachiro, T.;Yukinobu, I
  17. Chem. Pham. Bull v.27 no.11 The structures of four new lignans, Gomisin N, Gomisin O, Epigomisin O and Gomisin E and transformation of Gomisin of Gomisin N to Deangeloygomisin B Yukinobu, I.;Heihachiro, T.;Itiro, T.;Hiroshi, K.
  18. Chem. Pham. Bull v.28 no.8 The constituents of Schizandra chinensis BaILL. Ⅵ $13^C$Nuclear Magnetic Resonance Spect- roscophy of Divenzocylooctadiene Lignans Yukinobu, I.;Heihachiro, T.;Hiroshi, S.;Kaoru, N.;Itiro, Y.
  19. Chem. Pham. Bull v.30 no.9 The constituents of Schizandra chinensis BaILL. ⅩⅡ. Isolation and structure of a new lignan, Gomisin, Gomisin R, the absolute structure of Wuweizisu of Wuweizisu C and Isolation of Schisantherin D Yukinobu, I.;Heihachiro, T.;Yosioka, I.
  20. Planta medica v.65 Inhibition of Chitin Synthase Ⅱ by Catechins form Stem Bark of Taxus cuspidata Kim, S. U.;Hwang, E. I.;Nam, J. Y.;Son, K. H.;Bok, S. H.;Kim, H. E.;Kwon, B. M.
  21. Planta Medica v.65 Chitin synthae Ⅱ Inhibitory Activity of Ursolic acid, Isolated from Crataegus pinnatifida Jeong, T. S.;Hwang, E. I.;Lee, H. B.;Lee, E. S.;Kim, Y. K.;Min, B. S.;Bae, K. H.;Bok, S. H.;Kim, S. U.
  22. 약학회지 v.40 no.5 Candida와 Penicillum속 진균에 대한 천연물의 항진균 효과 검색 민병선;방규호;이준성;배기환
  23. Planta Medica v.65 Acyl-CoA : Chlolestrol Acyltran Acyltransferase inhibitory Activity of Lignans Isolated from Schizandra, Machilus and Magnolia Species Kwon, B. M.;Jung, H. J.;Lim, J. H.;Kim, Y. S.;Kim, M. K.;Kim, Y. K.;Bok, S. H.;Bae, K. H.;Lee, I. R.