Synthesis and In Vitro Antibacterial Activity of Quaternary Ammonium Cephalosporin Derivatives Bearing Oxazolidinone Moiety

  • Chung, In-Hwa (Biochemicals Research Center, Korea Institute of Science and Technology/Department of Chemistry, Korea University) ;
  • Kim, Choong-Sup (Biochemicals Research Center, Korea Institute of Science and Technology) ;
  • Seo , Jae-Hong (Biochemicals Research Center, Korea Institute of Science and Technology) ;
  • Chung, Bong-Young (Department of Chemistry, Korea University)
  • Published : 1999.12.01

Abstract

Several oxazolidinones having amine moiety were prepared to form a quaternay ammonium salt with cephalosporin nucleus, and antibacterial activity of the quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety were examined particularly with expectation of dual activity. However, the cephalosporin-oxazolidinone compounds revealed rather weaker antibacterial activity in vitro than their parent oxazolidinone and cephalosporin without showing any characteristic activity as expected.

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