Archives of Pharmacal Research
- Volume 22 Issue 6
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- Pages.579-584
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and In Vitro Antibacterial Activity of Quaternary Ammonium Cephalosporin Derivatives Bearing Oxazolidinone Moiety
- Chung, In-Hwa (Biochemicals Research Center, Korea Institute of Science and Technology/Department of Chemistry, Korea University) ;
- Kim, Choong-Sup (Biochemicals Research Center, Korea Institute of Science and Technology) ;
- Seo , Jae-Hong (Biochemicals Research Center, Korea Institute of Science and Technology) ;
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Chung, Bong-Young
(Department of Chemistry, Korea University)
- Published : 1999.12.01
Abstract
Several oxazolidinones having amine moiety were prepared to form a quaternay ammonium salt with cephalosporin nucleus, and antibacterial activity of the quaternary ammonium cephalosporin derivatives bearing oxazolidinone moiety were examined particularly with expectation of dual activity. However, the cephalosporin-oxazolidinone compounds revealed rather weaker antibacterial activity in vitro than their parent oxazolidinone and cephalosporin without showing any characteristic activity as expected.