Archives of Pharmacal Research
- Volume 22 Issue 6
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- Pages.549-553
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Antipruritic Effect of DA-5018m A Capsaicin Derivative, in Mice
- Kim, Dong-Hwan (Dept. of Toxicology, Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
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Ahn, Byoung-Ok
(Dept. of Toxicology, Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Kim, Soon-Hoe (Dept. of Toxicology, Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Kim, Won-Bae (Dept. of Toxicology, Research Laboratories, Dong-A Pharm. Co., Ltd.)
- Published : 1999.12.01
Abstract
The antipruritic effect of DA-5018m a capsaicin derivative, was examined in mice. Male ICR mice were topically pretreated with Zostrix-HP (0.075% capsaicin cream), 0.1%, 0.3% DA-5018 cream or cream base (control) twice daily for 4 days. One hour after the last application, itch was induced either by compound 48/80 (