YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Screening of $5{\alpha}-Reductase$ Inhibition and Comedolytic Effects from Natural Products

천연물로부터 $5{\alpha}-Reductase$ 활성억제 및 면포용해효과의 검색

  • 최승만 ((주)LG 화학 생활과학연구소) ;
  • 김창덕 ((주)LG 화학 생활과학연구소) ;
  • 이민호 ((주)LG 화학 생활과학연구소) ;
  • 최영호 ((주)LG 화학 생활과학연구소) ;
  • 랑문정 ((주)LG 화학 생활과학연구소) ;
  • 안호정 ((주)LG 화학 생활과학연구소) ;
  • 윤여표 (충북대학교 약학대학)
  • Published : 1999.06.01
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Abstract

The antibacterial activity against Propionibacterium acnes (P. acnes), $5{\alpha}-reductase$ inhibition and comedolytic effects are the important pharmacological target sites of antiacne drughs. We previously reported on the antibacterial activities against P. acnes by natural products. In the present study the screening of $5{\alpha}-reductase$ inhibition and comedolytic effects from natural products were performed. Seven natural products such as Angelica koreana, Sophora flavescens, Prunus persica, Bombyx mori, Areca catechu, Galla rhois and Gleditschia koraiensis perfectly inhibited the activity of $5{\alpha}-reductase$ at the concentration of 0.01% (w/v). Sixteen natural products which were shown to have the potent antibacterial activities against P.acnes or $5{\alpha}-reductase$ inhibition activities were assayed for the comedolytic test. In the results of comedolytic effects on experimentally-induced comedones (EIC), Sophora flavescens showed the strongest comedolytic effect on EIC, and Polygonum cuspidatum and Angelica koreana showed stronger comedolytic effects on EIC than azelaic acid used for a positive control at the concentration of 3% (w/v). These results suggest that several natural products including Sophora flavescens can be developed as noble antiacne agents.

Keywords

References

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