Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Eudesmin Inhibits Tumor Necrosis Factor-$\alpha$ Production and T cell Proliferation

  • Cho, Jae-Youl (R & D Center, Daewoong Pharmaceutical Co. Ltd./Department of Immunology, Windeyer Institute of Medical Sciences, University College London Medical School) ;
  • Yoo, Eun-Sook (R & D Center, Daewoong Pharmaceutical Co. Ltd.) ;
  • Baik, Kyoung-Up (R & D Center, Daewoong Pharmaceutical Co. Ltd.) ;
  • Park, Myung-Hwan (R & D Center, Daewoong Pharmaceutical Co. Ltd.)
  • Published : 1999.08.01
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Abstract

Possible antiinflammatory effect of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-$\alpha$ production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. the compound significantly inhibited TNF-$\alpha$, production by lipopolysaccaride (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-$\alpha$ production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.

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