Archives of Pharmacal Research
- 제22권3호
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- Pages.309-312
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- 1999
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Inhibition of Aromatase Activity by Flavonoids
- Jeong, Hyeh-Jean (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago) ;
- Shin, Young-Geun (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago) ;
- Kim, Il-Hyuk (College of Pharmacy, ChungAng University) ;
- Pezzuto, John-M. (Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago)
- 발행 : 1999.06.01
초록
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared form human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin