The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Neuroprotective Effects of Uncariae Ramulus et Uncus on the Brain Ischemia induced by Four-Vessel Occlusion in Rats

조구등(釣鉤藤)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과

Lee In-Hwan;Leem Kang-Hyun;Lee Jong-Seok;Suk Kyoung-Ho;Ahn Duk-Kyun;Park Ho-Koon;Kim Ho-Cheol
이인환;임강현;이종석;석경호;안덕균;박호군;김호철

  • Published : 19990000

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Abstract

Uncariae Ramulus et Uncus(UR, 釣鉤藤) has sweet in flavour and slightly cold in property, acting on the liver and pericardium channels. This drug was described in a medical classic as having the ability to remove "heat", check hyperfunction of the liver and relieve dizziness, tremors, and convulsions, and subdue "endogenous wind". So this study was planned to check the neuroprotective effect of UR on the global ischemia induced by 4-vessel occlusion in Wistar rats. and UR extract was lyophilized after extraction with $70\%$ methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. In 4-VO ischemia model, UR showed significantly neuroprotective effects(l,000 and 500 mg/kg of UR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about $23.0\%,\;19.0\%$ respectively. Consequently, Uncariae Ramulus et Uncus has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats. So we expect that Uncariae Ramulus et Uncus can be used as a drug for neurodegenerative disease.

Keywords

References

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