BMB Reports
- Volume 32 Issue 4
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- Pages.379-384
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- 1999
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- 1976-670X(eISSN)
Taxol-Induced Apoptosis and Nuclear Translocation of Mitogen-Activated Protein (MAP) Kinase in HeLa Cells
- Kim, Sung-Su (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Kim, Yoon-Suk (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Jung, Yon-Woo (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Choi, Hyun-Il (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Shim, Moon-Jeong (Department of Medical Technology, College of Health Science, Yonsei University) ;
- Kim, Tae-Ue (Department of Medical Technology, College of Health Science, Yonsei University)
- Published : 1999.07.31
Abstract
Taxol, a natural product with significant anti-tumor activity, stabilizes microtubules and arrests cells in the G2/M phase of the cell cycle. It has been reported that taxol has additional effects on the cell such as an increase in tyrosine phosphorylation of proteins and activation of mitogen-activated protein (MAP) kinase. This phosphorylated kinase translocates into the nucleus and phosphorylates its substrate c-jun, c-fos, ATF2, and ATF3. The MAP kinase family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. First examination was cytotoxicity and apoptosis-induced concentration with paclitaxel in HeLa cell. A half-maximal inhibition of cell proliferation (