대한본초학회지 (The Korea Journal of Herbology)

  • 제14권1호
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  • Pages.121-121
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  • 1999
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

천마(天麻)의 4-Vessel Occlusion으로 유발한 흰쥐 전뇌허혈에 대한 신경보호 효과

Neuroprotective Effect of Gastrodiae Rhizoma on Global Ischemia Induced by 4-Vessel Occlusion in Rats

김호철;안덕균
Kim Ho-Cheol;Ahn Duk-Kyun

  • 발행 : 19990000

⟨ 이전 논문 다음 논문 ⟩

초록

Gastrodiae Rhizoma(GR), the rhizoma of Gastrodia elata $B_L.$, has been used for the effect of calming the liver(平肝) in Traditional Korean Medicine. We hypothesized this effect of calming the liver has relations with the effects of curing stroke. So, this study was planned to check the neuroprotective effect of GR on the global ischemia induced by 4-vessel occlusion in Wister rats. GR extract was lyophilized with ethanol after reflux extraction with water. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of $CA_1$ pyramidal neurons were counted after 7 days of reperfusion under the cresyl violet staining. The result showed significant protective effects of samples compared with control group which was administrated with normal saline in the intraperitoneal injection of 1200mg/kg and 600mg/kg of Gastrodiae Rhizoma extracts at 0, 2 and 6 hours after inducing cerebral ischemia. We also observed the same results when it was injected at 30 minutes before inducing ischemia. The extract of GR did not lower body temperature at these dosages. Further study will be needed to separate the active ingredients of GR and study molecular biological mechanism for developing neuroprotective drug.

키워드

참고문헌

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